Actively Recruiting
CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease
Led by British Columbia Cancer Agency · Updated on 2025-02-11
10
Participants Needed
1
Research Sites
232 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Leptomeningeal disease is malignant seeding of the leptomeninges and presents with a variety of symptoms frequently impacting quality of life. With improvement in treatment options, rates of leptomeningeal disease are increasing and currently found in up to 9% of EGFR mutant NSCLC. Systemic therapy may be more effective if it can target the correct molecular aberration. The molecular characterization of central nervous system disease may differ from disease outside of the central nervous system. The aim of this pilot trial is to evaluate for molecular differences between cerebral spinal fluid (CSF) and blood circulating tumor DNA (ctDNA) through the use of ddPCR and BC Cancer NGS panel molecular testing.
CONDITIONS
Official Title
CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older at the time of informed consent
- Histologically or cytologically confirmed metastatic EGFR mutant non-small cell lung cancer
- Leptomeningeal disease confirmed by brain MRI or cerebrospinal fluid cytology
- ECOG performance status of 0 to 3
- Life expectancy of at least 8 weeks
- Adequate blood counts and organ function for testing
- Ability to give informed consent for study procedures
You will not qualify if you...
- Unable to undergo lumbar puncture due to low platelets, bleeding disorders, or inability to cooperate or consent
- Considered unfit by treating clinician to participate
- Spinal leptomeningeal disease seen on MRI spine that prevents safe lumbar puncture
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
BC Cancer
Vancouver, British Columbia, Canada, V5Z4E6
Actively Recruiting
Research Team
C
Cheryl Ho, MD
CONTACT
B
Barbara Melosky, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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