Actively Recruiting
CSF and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and CNS Metastases or no CNS Metastases
Led by Sunnybrook Health Sciences Centre · Updated on 2026-03-17
60
Participants Needed
1
Research Sites
50 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective, single-centre feasibility study of CSF ctDNA conducted at the Sunnybrook Odette Cancer Centre (SOCC), Toronto, Canada, including multiple solid tumor, stratified into cohorts according to CNS disease involvement, including leptomeningeal disease (Cohort A), parenchymal brain metastases (Cohort B), and no evidence of CNS metastases (Cohort C).
CONDITIONS
Official Title
CSF and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and CNS Metastases or no CNS Metastases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with a metastatic solid tumour with one of the following: leptomeningeal metastatic disease (with or without brain metastases), parenchymal brain metastases without leptomeningeal disease, or no CNS metastases
- Suitable for lumbar puncture and/or have an accessible Ommaya reservoir for CSF collection
- Eligible at any treatment stage, including those already treated for leptomeningeal disease
- Have active brain metastases, either newly diagnosed untreated lesions or progressing previously treated lesions
- May be re-enrolled if previously enrolled with negative CSF biomarkers and later have CNS disease progression
You will not qualify if you...
- Unable or unwilling to provide written informed consent (language barriers allowed with translator)
- Contraindications to lumbar puncture such as infection at puncture site, uncontrolled bleeding, severe thrombocytopenia (platelets <40,000/µL), inability to safely interrupt anticoagulants or antiplatelets, significant brain mass effect risk, or presence of vertebral hardware
AI-Screening
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Trial Site Locations
Total: 1 location
1
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M8Z 3X1
Actively Recruiting
Research Team
K
Katarzyna Jerzak, Dr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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