Actively Recruiting
CSF Metabolomics and Glymphatic Function in Patients Receiving VP- Shunt Surgery.
Led by Chang Gung Memorial Hospital · Updated on 2023-08-22
48
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In this randomized control study, the investigators intended to evaluate the influence of different anesthetics on postoperative cognitive dysfunction, neuroinflammation, CSF metabolomics, and glymphatic function in patients with normal pressure hydrocephalus for VP shunt surgery. The investigators assume that the use of dexmedetomidine infusion and proper anesthsia depth during general anesthesia, in addition to multi-model analgesia, might be helpful to enhance glymphatic function, reduce neuroinflammation, and decrease postoperative cognitive dysfunction.
CONDITIONS
Official Title
CSF Metabolomics and Glymphatic Function in Patients Receiving VP- Shunt Surgery.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with communicating hydrocephalus scheduled for elective VP shunt surgery under general anesthesia
- Age 60 years or older
- Conscious and clear
- Fluent in Chinese
- Expected hospital stay of at least 3 days after surgery
You will not qualify if you...
- Unstable preoperative condition such as unstable angina, congestive heart failure, or asthma attack within 4 weeks before surgery
- Severe liver or kidney dysfunction
- History of neuropsychological diseases including schizophrenia, Parkinson's disease, dementia, or stroke
- Preoperative cognitive impairment
- Preoperative delirium
- Preoperative depression
- Allergy to MRI contrast medium
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Linkou Chang Gung Memorial Hospital
Taoyuan, Taiwan, 33305
Actively Recruiting
Research Team
H
Huan-Tang Lin, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
3
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