Long-term Follow-up Study of Childhood Medulloblastoma Survivors Treated with Craniospinal Irradiation Using the SJMB12 Protocol

What this Trial Is About

Researchers are studying the long-term health and well-being of childhood medulloblastoma survivors treated with modern therapies like neurosurgery, risk-adapted radiotherapy, and chemotherapy. The study focuses on understanding lasting effects of treatment such as cognitive challenges, hearing loss, heart and lung fitness, endocrine and musculoskeletal issues, and infertility. It aims to determine which evaluations should be part of ongoing follow-up care for these survivors. Participants include childhood medulloblastoma survivors treated with radiation therapy on or according to the SJMB12 protocol at St. Jude Childrens Research Hospital. The study has two groups the CSIMEMPHIS group, which includes all eligible survivors, and the BRAINatomy2 group, which requires participants to tolerate MRI without sedation and have no history of significant posterior fossa syndrome. Participants undergo comprehensive health evaluations, including fMRI scans tailored to their treatment and follow-up needs. During the study, participants complete medical assessments targeting overall health and therapy-related toxicities, along with surveys about their health experiences. Some participants may have additional investigational fMRI scans depending on their group. Researchers will measure long-term health outcomes related to radiation dose, chemotherapy regimens, and radiation types. The study involves baseline and prospective follow-up evaluations to inform future care and research planning, with participation lasting until the studys completion in 2031.

CSIMEMPHIS: Long-term Follow-up of Medulloblastoma Survivors That Received Craniospinal Irradiation