Actively Recruiting
CSP #2026 - Beta Blocker Dialyzability on Cardiovascular Outcomes
Led by VA Office of Research and Development · Updated on 2026-01-09
2540
Participants Needed
8
Research Sites
240 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators aim to determine, using a point-of-care randomized controlled trial design, if hemodialysis patients, who are randomized to metoprolol succinate (a dialyzable, beta-1 selective beta blocker), have an improved cardiovascular outcome compared to those randomized to carvedilol (a non-dialyzable, non-selective beta blocker with alpha-1 antagonist properties). The investigators will also examine intervention practices to identify components that best support engagement and sustainability.
CONDITIONS
Official Title
CSP #2026 - Beta Blocker Dialyzability on Cardiovascular Outcomes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- On hemodialysis
- Receiving one of the following beta blockers through the VA pharmacy: metoprolol (succinate or tartrate), atenolol, labetalol, carvedilol, bisoprolol
You will not qualify if you...
- Impaired decision-making capacity
- Patients not receiving carvedilol who have a history of asthma
- Known hypersensitivity to any component of either drug
- Provider unwilling to sign a new medication order for a randomized patient
- No surrogate consent will be allowed
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
VA Long Beach Healthcare System, Long Beach, CA
Long Beach, California, United States, 90822
Actively Recruiting
2
North Florida/South Georgia Veterans Health System, Gainesville, FL
Gainesville, Florida, United States, 32608-1135
Actively Recruiting
3
Atlanta VA Medical and Rehab Center, Decatur, GA
Decatur, Georgia, United States, 30033-4004
Actively Recruiting
4
Iowa City VA Health Care System, Iowa City, IA
Iowa City, Iowa, United States, 52246-2292
Actively Recruiting
5
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Boston, Massachusetts, United States, 02130-4817
Not Yet Recruiting
6
Minneapolis VA Health Care System, Minneapolis, MN
Minneapolis, Minnesota, United States, 55417-2309
Actively Recruiting
7
Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE
Omaha, Nebraska, United States, 68105-1850
Actively Recruiting
8
New Mexico VA Health Care System, Albuquerque, NM
Albuquerque, New Mexico, United States, 87108-5153
Actively Recruiting
Research Team
C
Christopher M Donnelly
CONTACT
J
Jade Fiotto
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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