Actively Recruiting
CSP Versus BiVP for Heart Failure Patients With RVP Upgraded to Cardiac Resynchronization Therapy
Led by The First Affiliated Hospital with Nanjing Medical University · Updated on 2026-05-14
66
Participants Needed
1
Research Sites
165 weeks
Total Duration
On this page
Sponsors
T
The First Affiliated Hospital with Nanjing Medical University
Lead Sponsor
S
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The present study is a prospective, multicenter, non-inferiority, randomized controlled trail. It aims to investigate whether the efficacy of conduction system pacing (CSP) is non-inferior to biventricular pacing (BiVP) in patients with heart failure and right ventricular pacing (RVP) requiring upgrading to cardiac resynchronization therapy (CRT).
CONDITIONS
Official Title
CSP Versus BiVP for Heart Failure Patients With RVP Upgraded to Cardiac Resynchronization Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with symptomatic heart failure (LVEF <50%) after right ventricular pacing for at least 3 months
- NYHA class II-IV
- NT-proBNP >125pg/mL in patients with sinus rhythm, NT-proBNP >250pg/mL in patients with atrial fibrillation
- Right ventricular pacing percentage >40%
- Adult patients aged 18-80
- With informed consent signed
You will not qualify if you...
- History of acute myocardial infarction within 3 months before enrollment
- Frequent premature ventricular contraction (>15%) or malignant ventricular arrhythmia which is difficult to control
- History of valvular heart disease intervention within 3 months before enrollment
- After mechanical tricuspid valve replacement
- Ventricular septal hypertrophy (≥15mm during diastole)
- Complex congenital heart disease
- History of heart transplantation
- Enrollment in any other study
- Pregnant or with child-bearing plan
- A life expectancy of less than 12 months
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital with Nanjing Medical University
Nanjing, Jiangsu, China, 210029
Actively Recruiting
Research Team
J
Jiangang Zou
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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