Actively Recruiting
CT-95 in Advanced Cancers Associated With Mesothelin Expression
Led by Context Therapeutics Inc. · Updated on 2025-07-31
70
Participants Needed
8
Research Sites
191 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a Phase 1a/1b open-label, dose escalation study to evaluate the safety and efficacy of CT-95 (study drug), a humanized T cell engaging bispecific antibody targeting Mesothelin, in subjects with advanced solid tumors associated with Mesothelin expression.
CONDITIONS
Official Title
CT-95 in Advanced Cancers Associated With Mesothelin Expression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- ECOG performance status of 0 or 1
- Advanced cancers associated with Mesothelin expression
- Evaluable disease according to RECIST 1.1 or mRECIST criteria
- Adequate organ function
You will not qualify if you...
- Uncontrolled significant active infection or any medical condition that would prevent study participation
- Prior treatment with MSLN-targeted CD3 or CAR-T therapy
- Current participation in another investigational clinical trial
- Evidence of leptomeningeal disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
Context Investigational Site
Denver, Colorado, United States, 80218
Actively Recruiting
2
Context Investigational Site
Chicago, Illinois, United States, 60637
Actively Recruiting
3
Context Investigational Site
Grand Rapids, Michigan, United States, 49546
Actively Recruiting
4
Context Investigational Site
Hackensack, New Jersey, United States, 07601
Actively Recruiting
5
Context Investigational Site
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
6
Context Investigational Site
Nashville, Tennessee, United States, 37203
Actively Recruiting
7
Context Investigational Site
San Antonio, Texas, United States, 78229
Actively Recruiting
8
Context Investigational Site
San Antonio, Texas, United States, 78229
Actively Recruiting
Research Team
C
Curtis Reinard
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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