Actively Recruiting
CT Evaluation of Carotid Plaque Components
Led by University of Pennsylvania · Updated on 2025-11-25
70
Participants Needed
1
Research Sites
269 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to validate the diagnostic performance of photon counting/spectral CT to distinguish tissue components in ischemic stroke with MRI, semi-automated segmentation software or histology as the reference standard. The main question\[s\] it aims to answer are: 1. Presence or absence of calcium, hemorrhage, and lipid plaque components as determined on CT will be confirmed with carotid MRI, segmentation quantitative (e.g., volume) output from segmentation software, or histologic staining. 2. Volumes of hemorrhage, lipid, and calcium components will be measured to determine plaque phenotype and correlated with ipsilateral intracranial stroke burden. Participants will be asked to do the following: Aim 1: * 1 Photon counting/spectral CT angiography of the neck * 1 Research Carotid/Neck MRI of the carotid arteries (if eligible) Aim 2: * 1 Research Carotid/Neck MRI of the carotid arteries (if eligible) * 1 Photon counting/spectral CT angiography of the neck * 1 Carotid plaque tissue from participants surgery will be retrieved, imaged, and stained (if eligible)
CONDITIONS
Official Title
CT Evaluation of Carotid Plaque Components
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with symptomatic carotid stenosis with ipsilateral ischemic infarcts attributable to the carotid disease
- At least 1mm of noncalcified plaque on the same side as the stroke
- Brain MRI showing ischemic infarct related to the ipsilateral carotid disease
- Patients planned to undergo carotid endarterectomy surgery
- Patients able to read and understand English
- Participants must sign the informed consent form
You will not qualify if you...
- Patients younger than 18 years old
- Women who are pregnant and/or nursing
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Pennsylvania Hospital
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
M
Marisa Sanchez
CONTACT
L
Leeanne Lezotte
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here