Study to Reduce Lung Biopsy Risks Using Fluid Injection in the Pleural Cavity and Patient Positioning During CT-Guided Lung Biopsy

What this Trial Is About

Researchers are studying whether injecting a small amount of fluid into the pleural cavity during a CT-guided lung biopsy can reduce the risk of pneumothorax, a common complication. This randomized controlled study focuses on patients who need a lung biopsy due to suspicious or unclear lung lesions and aims to improve biopsy safety by also considering patient positioning to biopsy gravity-dependent lung areas. Participants in this study will be randomly assigned to receive either an injection of up to 20 ml of sodium chloride fluid into the pleural cavity before biopsy or no fluid. The biopsy procedure involves taking three samples using an 18G or 20G coaxial needle, performed by Interventional Radiology. The biopsy itself is clinically indicated and not specifically for the study. Data, including images, lab results, clinical information, and pathology findings, will be collected and analyzed. During the study, researchers will monitor patients immediately after biopsy for complications such as pneumothorax, bleeding, chest tube placement, and air embolism, typically within about five minutes. Records and imaging from hospital systems will be reviewed for analysis. Participation involves the biopsy procedure as part of usual care, with additional data collection to assess risks. The study is planned to run until April 2027.

CT-guided Lung Biopsy Risk Optimization Method