Study of Reduced Dose Iodinated Contrast in Dual Energy CT for Planning Transcatheter Aortic Valve Replacement TAVR

What this Trial Is About

Researchers are exploring whether lowering the dose of iodinated intravenous contrast in CT scans can be effective for presurgical planning of transcatheter aortic valve replacement TAVR. This study addresses the challenge of global shortages of iodine-based contrast and aims to find ways to reduce contrast use while maintaining image quality. The potential benefits include cost savings for hospitals and a reduced risk of acute kidney injury, especially for patients with impaired kidney function. Participants will undergo CT imaging using dual energy CT scanners that allow monoenergetic image reconstruction, enhancing iodine contrast in images. The study involves two cohorts one receiving a reduced contrast dose of one-third the standard amount 33 ml, and if those images are satisfactory, a second cohort receiving one-fourth the standard dose 25 ml. If images with the lower dose are not satisfactory, the dose may be increased to 50 ml. During the study, participants will have their imaging assessed for diagnostic quality over an 18 to 24 month period. The study includes monitoring of image quality and safety, with the primary outcome focusing on the diagnostic quality of CT images. Participants will be followed through the imaging process, with no masking or randomization involved, and the entire study is planned to complete by March 2028.

CT TAVR Abdomen Study