Actively Recruiting
ctDNA in Cutaneous Squamous Cell Carcinoma
Led by Massachusetts Eye and Ear Infirmary · Updated on 2026-03-30
60
Participants Needed
1
Research Sites
214 weeks
Total Duration
On this page
Sponsors
M
Massachusetts Eye and Ear Infirmary
Lead Sponsor
H
Haystack Oncology, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to test the potential for a liquid biopsy assay to detect residual disease after surgery in patients with cutaneous squamous cell carcinoma as well as the potential for this assay to monitor response to immunotherapy treatment.
CONDITIONS
Official Title
ctDNA in Cutaneous Squamous Cell Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with surgically resectable primary CSCC with perineural invasion (nerve >0.1mm) or at least 2 high-risk features (size > 2cm, recurrent CSCC, lymphovascular invasion, immunosuppression, poor differentiation, or invasion beyond subcutaneous fat)
- Patients with surgically resectable regional metastases not receiving neoadjuvant therapy
- Patients with resectable AJCC (8th ed) Stage II, III, or IV(M0) CSCC treated with neoadjuvant immunotherapy as standard care
- Patients with unresectable locally advanced or metastatic CSCC, AJCC (8th ed) Stage II, III, or IV, receiving immunotherapy as standard care
You will not qualify if you...
- Patients with CSCC not suitable for surgical resection
- Patients receiving or undergoing systemic therapies outside standard of care
- Patients ineligible for neoadjuvant treatment
- Patients enrolled in conflicting clinical trials
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Massachusetts Eye and Ear
Boston, Massachusetts, United States, 02114
Actively Recruiting
Research Team
M
Michael Cheung, MSc, CCRP
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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