Actively Recruiting
CtDNA as a Novel Biomarker of Treatment Efficacy in Patients With Ovarian Cancer
Led by Xinhua Hospital, Shanghai Jiao Tong University School of Medicine · Updated on 2026-04-24
100
Participants Needed
1
Research Sites
317 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a prospective observational clinical trial. Patients who were diagnosed and treated for the first time were enrolled and their surgical pathology was confirmed to be high-grade serous ovarian cancer. At the same time, these patients will receive first-line maintenance treatment with PARP inhibitors after traditional chemotherapy. During the trial period, patients' plasma will be collected before surgery, after chemotherapy, during targeted maintenance therapy, and during disease progression, and ctDNA-specific genomes will be detected, and clinical data will be collected over the same period. It is expected that specific ctDNA can be used to predict the efficacy of PARP inhibitors in patients with ovarian cancer, and to detect the recurrence of the disease early.
CONDITIONS
Official Title
CtDNA as a Novel Biomarker of Treatment Efficacy in Patients With Ovarian Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ovarian cancer diagnosed and treated for the first time
- Pathological confirmation of epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer
- Disease stage II to IV with planned surgery after evaluation
- Age 18 years or older
- Ability to understand the study and provide informed consent
You will not qualify if you...
- Non-epithelial ovarian cancer confirmed by pathology
- Unable to undergo surgery after evaluation
- Other malignant tumors diagnosed within five years before or at enrollment
- Refusal to use clinical first-line targeted drugs
- Severe mental illness
- Severe cardiovascular disease, uncontrolled infection, or other uncontrolled serious illnesses
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Shanghai, China
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here