Evaluation of the Ability of CTFFR to Determine Non-significant Lesions of Coronary Disease Based on MACE in One-year Follow-up of Patients (Seeing Beyond the Stenosis: CTFFR and MACE in a One-Year Follow-Up)

What this Trial Is About

This research investigates the use of a diagnostic test called fractional flow reserve derived from CT angiography (NIFFR) in patients with known or suspected chronic coronary syndrome (CAD). It focuses on patients who have at least one coronary artery lesion with 50-70% narrowing. The study aims to see if NIFFR can identify lesions that are not significant and predict major heart-related events over a one-year period. Participants had coronary computed tomography angiography (CCTA) and invasive coronary angiography (ICA) with FFR measurements. The study included 250 patients with intermediate coronary lesions and NIFFR values above 0.80. Their coronary artery lesions were carefully measured and classified using advanced imaging software. The study groups compared patients with nonsignificant NIFFR and those with significant NIFFR values. Over one year, patients were followed closely, with visits every three months and phone calls to monitor for major adverse cardiovascular events (MACE), including heart-related death, acute coronary syndrome, unexpected procedures to restore blood flow, and hospitalizations due to heart problems. Researchers collected detailed patient information including heart function, lesion characteristics, and cardiovascular risk factors. Outcomes such as MACE, bleeding, and shortness of breath were tracked to evaluate the diagnostic value of NIFFR in predicting heart health risks.

CTFFR and Prediction of Non-Significant CAD Lesions