Cortical Transit Time on Diuretic Renogram as an Early Marker of Significant Obstruction in Antenatally Detected Uretero-pelvic Junction Syndrome

What this Trial Is About

Researchers are studying ureteropelvic junction obstruction (UPJO) detected before birth, a condition where urine flow from the kidney is blocked, which can cause kidney damage if untreated. This study aims to find early markers of significant obstruction to better decide when surgery is needed. Currently, doctors use diuretic renography and ultrasound, but these methods often detect problems only after kidney damage begins. The study focuses on measuring cortical transit time (CTT) and positional changes in kidney measurements as potential early indicators. Participants will undergo bilateral ultrasonography to measure the antero-posterior renal pelvic diameter (APRPD) in different positions and diuretic renography to measure cortical transit time. These non-invasive imaging tests will be performed at specified intervals to assess kidney function and obstruction severity. The study will compare these two markers to evaluate their ability to predict worsening obstruction. Families of infants aged 4 to 8 weeks with a confirmed unilateral UPJO will be involved. Researchers will monitor changes in APRPD through ultrasound at 3, 6, and 12 months, focusing on whether an increase of 4 mm or more occurs in the first year. The study includes regular imaging and clinical assessments, with the goal to improve early diagnosis and management decisions, reducing unnecessary surgeries and better protecting kidney health.

CTT on Renogram as an Early Marker of Significant Obstruction in Uretero-pelvic Junction Syndrome