Actively Recruiting
Cue Effects in Human Addiction: Pavlovian to Instrumental Transfer
Led by Charite University, Berlin, Germany · Updated on 2024-08-21
300
Participants Needed
2
Research Sites
214 weeks
Total Duration
On this page
Sponsors
C
Charite University, Berlin, Germany
Lead Sponsor
T
Technische Universität Dresden
Collaborating Sponsor
AI-Summary
What this Trial Is About
Individuals with substance use disorders (SUD) have to cope with drug-related cues and contexts, which can affect instrumental drug seeking as shown with Pavlovian to instrumental transfer (PIT) paradigms in animals and humans. The investigators aimed to investigate the impact of acute and chronic stress on Pavlovian-to-instrumental transfer (PIT), how PIT it is associated with cognitive control abilities and whether such effects predict losing vs. regaining control in subjects with AUD. Moreover, the investigators aimed to develop a novel full transfer task that assesses both, general and specific PIT to investigate whether specific PIT differs between alcohol use disorder (AUD) and control subjects.
CONDITIONS
Official Title
Cue Effects in Human Addiction: Pavlovian to Instrumental Transfer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females between 16 and 65 years of age
- AUD subjects must meet at least 2 DSM-5 criteria for alcohol-related disorder and have an AUDIT score greater than 4
- Daily smokers: smoke every day during the last three months
- Non-daily smokers: smoke at least once but less than 7 days per week during the last three months
- Ability to consent to the study and complete questionnaires
- Sufficient German language skills
- Availability between 3pm and 6pm on 2 consecutive days (for Experiment 1 acute stress question)
- Females only: must be in the luteal phase (for Experiment 1 acute stress question)
You will not qualify if you...
- Lifetime diagnosis of bipolar disorder, schizophrenia or schizophrenia spectrum disorder, substance dependence except for alcohol, nicotine, or cannabis
- Current diagnosis of depressive episode or suicidal ideation
- Past traumatic brain injury or severe neurological disease such as dementia, Parkinson's disease, or multiple sclerosis
- Pregnancy or breastfeeding
- Use of medications that interact with the central nervous system within 10 days prior to participation or less than 4 half-lives after last ingestion
- Contraindications for MRI such as pacemakers, metallic or electronic implants, metallic splinters, or surgical staples
- Color vision deficiency
- Sensorineural hearing loss of 30 dB or greater
- Tinnitus
- Presence of claustrophobia
- Acute alcohol intoxication or drug intoxication at MRI appointments
- For women only: not peri- or postmenopausal and not taking contraceptives (for Experiment 1 acute stress question)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Charite - Universitätsmedizin Berlin
Berlin, Germany, 10117
Actively Recruiting
2
Technische Universität Dresden
Dresden, Germany, 01307
Actively Recruiting
Research Team
A
Andreas Heinz, Prof., MD, PhD
CONTACT
M
Maximilian Pilhatsch, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here