Effects of Curcumin and EGCG Supplements on Brain Health and Mood in Adults Aged 18 to 50

What this Trial Is About

Researchers are evaluating whether daily supplements of curcumin and epigallocatechin gallate EGCG can improve mood disturbance and increase serum brain derived neurotrophic factor BDNF levels in adults aged 18 to 50 who have moderate mood symptoms as measured by a depression scale. This randomized, placebo-controlled trial aims to understand the effects of these supplements on mood and brain health markers over an 8-week period. Participants will be randomly assigned to either the intervention group receiving 1,330 mg of curcumin and 350 mg of EGCG daily or a placebo group. The study lasts 8 weeks, during which participants will consume their assigned supplements each day. The trial includes baseline and follow-up assessments at weeks 0, 4, and 8, including mood questionnaires and blood tests to measure serum BDNF. During the study, participants will have blood drawn at the start and end of the 8 weeks to measure BDNF levels. They will complete mood and lifestyle questionnaires at weeks 0, 4, and 8 to track changes in mood disturbance, anxiety, stress, sleep quality, physical activity, and diet. Daily reminders will help participants adhere to taking their supplements. The main outcomes measured are changes in mood disturbance scores and serum BDNF after 8 weeks of supplementation.

Curcumin and EGCG Supplementation to Improve Serum BDNF and Mood Disturbance