Actively Recruiting
A Randomized Controlled Trial to Determine the Effects of Curcumin and Epigallocatechin Gallate Supplementation on Serum Brain Derived Neurotrophic Factor and Mood Disturbance in Adults
Led by Auburn University · Updated on 2025-02-14
64
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating whether daily supplements of curcumin and epigallocatechin gallate (EGCG) can improve mood disturbance and increase serum brain derived neurotrophic factor (BDNF) levels in adults aged 18 to 50 who have moderate mood symptoms as measured by a depression scale. This randomized, placebo-controlled trial aims to understand the effects of these supplements on mood and brain health markers over an 8-week period. Participants will be randomly assigned to either the intervention group receiving 1,330 mg of curcumin and 350 mg of EGCG daily or a placebo group. The study lasts 8 weeks, during which participants will consume their assigned supplements each day. The trial includes baseline and follow-up assessments at weeks 0, 4, and 8, including mood questionnaires and blood tests to measure serum BDNF. During the study, participants will have blood drawn at the start and end of the 8 weeks to measure BDNF levels. They will complete mood and lifestyle questionnaires at weeks 0, 4, and 8 to track changes in mood disturbance, anxiety, stress, sleep quality, physical activity, and diet. Daily reminders will help participants adhere to taking their supplements. The main outcomes measured are changes in mood disturbance scores and serum BDNF after 8 weeks of supplementation.
CONDITIONS
Brief Title
Curcumin and EGCG Supplementation to Improve Serum BDNF and Mood Disturbance
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults age 18-50
- Depression subscale score greater than 9 on the DASS-21
- No change in medications or supplements over the past 3 months
- Can read and speak English
You will not qualify if you...
- Currently consume curcumin or green tea daily
- Currently pregnant, nursing, or trying to become pregnant
- Currently diagnosed with a perimenopausal disorder
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 8 weeks
Participants receive daily supplementation with either curcumin and EGCG or placebo for 8 weeks. Mood questionnaires and serum BDNF assessments are completed at the start, midpoint, and end of treatment. Dietary recalls are also collected at these times.
3 visits (in-person) at weeks 0, 4, and 8
Trial Site Locations
Total: 1 location
1
Auburn University School of Kinesiology
Auburn, Alabama, United States, 36849
Actively Recruiting
Research Team
A
Aidan Cavanah, MSc
A
Andrew Fruge, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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