Actively Recruiting
Curcumin Supplementation in Cervical Cancer
Led by National Institute of Cancerología · Updated on 2025-05-25
30
Participants Needed
1
Research Sites
149 weeks
Total Duration
On this page
Sponsors
N
National Institute of Cancerología
Lead Sponsor
S
Sabinsa Corporation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Brief Summary. The goal of this pilot study is to learn about the effect of curcumin supplementation in locally advanced cervical cancer patients. The main questions it aims to answer are: * Does curcumin supplementation increase the levels of p53 and apoptosis in tumor cells from cervical cancer patients? * At which dose of curcumin supplementation is the broader effect observed for p53 expression and apoptosis in tumor cells from cervical cancer patients? * Are all doses safe for supplementation? Participants will be asked to take curcumin tablets throughout their cancer treatment. Researchers will compare 6 different groups, each group will receive a different dose of curcumin with or without piperin, to see the dose with the broader effect and safety of curcumin supplementation: 1. 1 g of curcumin 2. 1 g of curcumin + piperine 3. 3 g of curcumin 4. 3 g of curcumin + piperine 5. 6 g of curcumin 6. 6 g of curcumin + piperine
CONDITIONS
Official Title
Curcumin Supplementation in Cervical Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Understanding the nature of the study and providing written consent
- Women older than 18 years
- ECOG performance status between 0 and 2
- Willing and able to follow scheduled visits, treatment plans, and lab tests
- Diagnosed with histological cervical cancer (squamous cell, adenosquamous, adenocarcinoma, or glassy cell carcinoma)
- Clinical stage IB3 to IVA (FIGO 2018)
- Eligible for concomitant chemoradiotherapy followed by brachytherapy
- Measurable disease by imaging (CT, MRI, or PET-CT) according to RECIST v1.1 criteria
- No prior chemoradiotherapy treatment
- Hemoglobin level of at least 10 g/dL
- Leukocyte count of at least 4000/mm3
- Platelet count of at least 100,000/mm3
- Adequate liver function
You will not qualify if you...
- Receiving nutritional treatment or dietary supplements containing turmeric, ginger, or related spices
- Having uncontrolled illnesses or active infections that prevent chemotherapy
- Receiving an experimental drug treatment simultaneously
- Diagnosed with vesicovaginal or vesicorectal fistula
- Having previous or other cancers except non-melanoma skin cancer
AI-Screening
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Trial Site Locations
Total: 1 location
1
Instituto Nacional de Cancerología
Mexico City, Mexico City, Mexico, 14080
Actively Recruiting
Research Team
D
Denisse Castro-Eguiluz, RDN, PhD
CONTACT
A
Alejandro García Carrancá, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
6
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