Actively Recruiting
The CurePSP Genetics Program
Led by Massachusetts General Hospital · Updated on 2026-01-14
1000
Participants Needed
1
Research Sites
325 weeks
Total Duration
On this page
Sponsors
M
Massachusetts General Hospital
Lead Sponsor
C
CurePSP Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is an observational, prospective genetic study. It aims to obtain DNA for research and testing from patients with PSP, CBS, MSA, and related neurological conditions and their families. Up to 1,000 adults who have been clinically diagnosed with PSP, CBS, MSA, or related neurological conditions will be enrolled. The study intervention involves sequencing of participant blood samples using non-CLIA-approved whole genome sequencing at the National Institutes of Health. Pathogenic variants that are deemed possibly related to these conditions will be confirmed using CLIA-approved testing. The study involves minimal risk to participants.
CONDITIONS
Official Title
The CurePSP Genetics Program
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 35 years or older with a clinical diagnosis of PSP, CBS, MSA, or related neurological disease as confirmed by their healthcare provider, or unaffected family members with a family history of these neurodegenerative conditions
- Meet Movement Disorder Society Clinical Diagnostic Criteria for Possible or Probable PSP, clinically established or probable MSA, or Armstrong criteria for possible or probable CBS
- Willing to undergo genetic testing and may choose to receive relevant genetic test results
- Able to give informed consent in writing or electronically, or through a legally authorized representative, and have completed the informed consent form
- Able to perform study activities or have a designee to assist with activities including online or oral surveys
You will not qualify if you...
- Blood transfusion within the past 3 months
- Active hematologic malignancies such as lymphoma or leukemia
- Bone marrow transplant within the past 5 years
- Younger than 35 years or younger than the age of majority in applicable states at the time of consenting
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
Research Team
M
MGH Research Coordinators
CONTACT
C
CurePSP Hope Line
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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