Study of Cushings Syndrome Effects and Recovery Over Time in Adults

What this Trial Is About

Researchers are studying patients with Cushings syndrome to understand how the condition affects physical function, quality of life, and circadian rhythms both before and after treatment. The study aims to evaluate the negative impacts of Cushings syndrome on health-related quality of life and physical abilities, as well as how the condition alters circadian rhythms in the body and peripheral tissues. The research also explores how some of these complications may improve after the disease is controlled. This observational study does not involve any interventions or treatments assigned by the researchers. Instead, it follows patients diagnosed with endogenous Cushings syndrome, including both ACTH-dependent and ACTH-independent types, over time to monitor changes related to their condition and treatment. Assessments occur at baseline, then again at 3 months and 1 year after treatment to observe changes in various health measures. Participants will undergo evaluations including quality of life questionnaires, blood pressure checks, tests of arterial stiffness and endothelial function, insulin resistance, body composition, bone density, physical performance tests, and sleep and activity monitoring. Researchers will also analyze gene expression in blood and tissue samples and measure hormone and metabolite levels in urine. Safety and mental health are assessed with standardized scales. The total follow-up period for each participant is approximately one year after treatment initiation.

Cushing's Syndrome Before and After Treatment (CORRECT)