Actively Recruiting
CW2IP2: Imaging and Diagnostic Assessments
Led by University of Pennsylvania · Updated on 2026-01-07
94
Participants Needed
1
Research Sites
262 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This current protocol will provide the key data to help determine the specificity of our to-be-developed radiotracers by implementing a multi-site diagnostic assessment core and PET imaging of A-beta amyloid (may be completed at some sites as part of another protocol) that is commonly deposited in the brains of people with Parkinson's Disease (PD), Multiple System Atrophy (MSA), Progressive Supranuclear Palsy (PSP) or Frontotemporal Dementia (FTD) as well as healthy controls. This multicenter U19 grant is centered at U Pennsylvania (U Penn) (PI: Robert Mach) in collaboration with U Pittsburgh (Pitt), Yale University, U of California at San Francisco (UCSF) and Washington University in St. Louis (WU). U Penn will act as the single IRB of Record (sIRB) for this multi-center project and subjects will be recruited from all sites.
CONDITIONS
Official Title
CW2IP2: Imaging and Diagnostic Assessments
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged 40 to 85 years, both male and female
- Willing and able to provide written informed consent or have a Legally Authorized Representative (LAR) provide consent
- Clinical diagnosis confirmed by consensus committee for Parkinson's Disease, Multiple System Atrophy, Progressive Supranuclear Palsy, Frontotemporal Dementia, or healthy control
You will not qualify if you...
- Females who are pregnant or breastfeeding at the time of screening
- Parkinsonism forms other than Parkinson's Disease, Progressive Supranuclear Palsy, and Multiple System Atrophy
- Major psychiatric disorders such as schizophrenia or bipolar disorder
- History of significant or ongoing alcohol or substance abuse
- Contraindications or inability to tolerate imaging, arterial line or IV placement, or blood draw procedures
- Implanted medical devices or other contraindications to MRI
- Any current medical condition that could compromise safety or study participation
- Refusal to consent to postmortem brain donation (except healthy controls)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
E
Erin o Schubert
CONTACT
R
Refatun Momo
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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