Actively Recruiting
The CyberChallenge Trial How Much is Too Much - What is the Role of Cyberknife Radiosurgery in Patients With Multiple Brain Metastases?
Led by University Hospital Heidelberg · Updated on 2026-03-10
190
Participants Needed
1
Research Sites
313 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients suffering from malignancies in advanced stages often develop brain metastases, which limit both the life span and the quality of life. Therapy options for multiple brain metastases may vary and range from stereotactic radiosurgery (SRS), whole-brain radiotherapy (WBRT), chemotherapy, immunotherapy to palliative best supportive care. Especially the efficacy and toxicity of SRS compared to WBRT in patients with extensive brain metastases (\>4) is not yet clear but of incremental relevance in this seriously ill cohort with a limited life span. These health-impaired patients might especially profit from a less toxic treatment that is also time sparing with 1 or few sessions in SRS versus 10 sessions in WBRT. On the other hand, no compromises in efficacy want to be done.
CONDITIONS
Official Title
The CyberChallenge Trial How Much is Too Much - What is the Role of Cyberknife Radiosurgery in Patients With Multiple Brain Metastases?
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed malignant illness
- 4 to 15 suspect intracranial lesions confirmed by MRI
- Age 18 years or older
- For women with childbearing potential and men, use of adequate contraception
- Ability to understand the clinical trial and its consequences
- Written informed consent before enrollment
You will not qualify if you...
- Refusal to participate in the study
- Inability to tolerate irradiation as per protocol
- Small-cell lung cancer or lymphoma as primary malignancy
- More than 15 suspect intracranial lesions
- Presence of leptomeningeal disease
- Previous brain radiotherapy
- Not recovered from acute high-grade toxicities of prior treatments
- Pregnant or lactating women
- Participation in another competing clinical study
- Contraindications to MRI such as pacemaker, defibrillator, certain valve replacements, or metal implants
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University Hospital of Heidelberg, Radiation Oncology
Heidelberg, Germany, 69120
Actively Recruiting
Research Team
T
Tanja Eichkorn, MD
CONTACT
A
Adriane Hommertgen, Phd
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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