Actively Recruiting
Cybersickness Prevention and Mitigation in Virtual Reality for Healthy Volunteers
Led by National Human Genome Research Institute (NHGRI) · Updated on 2026-05-22
150
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating a new software called Motion Reset to reduce cybersickness symptoms in healthy adults using virtual reality (VR). Cybersickness is similar to motion sickness and can cause eye strain, nausea, dizziness, or headache. This study aims to assess whether Motion Reset can prevent these symptoms during VR use. The study is interventional, with participants randomly assigned to different groups to compare various VR experiences. Participants will be divided into three groups: one will use the Motion Reset VR experience designed to prevent cybersickness, another will use a placebo VR experience that does not target cybersickness prevention, and the third group will have no VR exposure initially. After this, all participants will play a commercial VR game called Jurassic World Aftermath for up to 20 minutes while being monitored for discomfort. They can stop playing at any time if they feel too uncomfortable. During the study visit, which lasts about one hour, participants will learn to use the VR equipment and complete multiple questionnaires about their symptoms and experience. Researchers will collect self-reported data before, during, and after VR use to measure cybersickness symptoms and assess the effectiveness of the Motion Reset software. The study will also monitor if participants stop using VR due to discomfort, with the entire process designed to ensure participant safety and comfort.
CONDITIONS
Brief Title
Cybersickness Prevention and Mitigation in Virtual Reality for Healthy Volunteers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provision of signed and dated informed consent form
- Willingness to comply with all study procedures and availability for the duration of the study
- Aged 18 to 60 years
- Ability to read, speak, and write in English
- Normal or corrected-to-normal hearing
- Normal vision or corrected-to-normal without use of glasses; contact lenses allowed
You will not qualify if you...
- Motion sickness frequency rating of 0, 9, or 10 on a 0-10 scale
- History of photo-sensitive seizure disorders, vestibular disorders, or conditions causing nausea, dizziness, vertigo, ataxia, or incoordination
- Known pregnancy
- Current use of medications or supplements that inhibit nausea, such as Zofran or Phenergan
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Single session
Participants undergo virtual reality activities which include an active intervention, placebo experience, or no intervention followed by exposure to a VR-based game to assess cybersickness symptoms.
1 visit (in-person)
Trial Site Locations
Total: 2 locations
1
Iowa State University
Ames, Iowa, United States, 50011
Actively Recruiting
2
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
S
Susan J Persky, Ph.D.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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