Actively Recruiting
Cybersickness Prevention and Mitigation in Virtual Reality for Healthy Volunteers
Led by National Human Genome Research Institute (NHGRI) · Updated on 2026-05-11
150
Participants Needed
2
Research Sites
70 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: People use virtual reality (VR) technology to play games, socialize, work, or receive medical care. Some people have "cybersickness" after using VR. Cybersickness is similar to motion sickness. Symptoms include eye strain, nausea, dizziness, or headache. The symptoms are usually mild and go away after the person stops using VR. New software called Motion Reset is being designed to reduce symptoms of cybersickness during VR use. Objective: To see if Motion Reset software can reduce cybersickness in people using VR. Eligibility: Healthy adults aged 18 to 60 years. Design: Participants will have 1 clinic visit that will last about 1 hour. They will answer questions about how they are feeling. They will learn how to use the VR headset and the handheld game controllers. The study will be broken into 2 parts. For the first part, participants will be assigned to 1 of 3 groups: Group 1 will participate in a VR experience designed to prevent cybersickness. They will view screens and move around while they press buttons on a controller. Group 2 will participate in a VR experience that is not designed to prevent cybersickness. They will view screens and move around while they press buttons on a controller. Group 3 will have no VR experience. Participants will complete 2 questionnaires about their experiences in the first part of the study. For the second part, all participants will spend up to 20 minutes playing a commercial VR game called Jurassic World Aftermath. Every few minutes, they will be asked if they are experiencing discomfort. After playing the game, participants will complete 12 questionnaires about their experience....
CONDITIONS
Official Title
Cybersickness Prevention and Mitigation in Virtual Reality for Healthy Volunteers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent form
- Willingness to comply with all study procedures and available for study duration
- Aged 18 to 60 years
- Ability to read, speak, and write in English
- Normal or corrected-to-normal hearing
- Normal vision or corrected-to-normal without glasses (contact lenses allowed)
You will not qualify if you...
- Self-assessed motion sickness frequency of 0, 9, or 10 on a 0-10 scale
- History of photo-sensitive seizure disorders, vestibular disorders, or conditions causing nausea, dizziness, vertigo, ataxia, or incoordination
- Known pregnancy
- Current use of medications or supplements that prevent nausea (e.g., Zofran/ondansetron, Phenergan/promethazine)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Iowa State University
Ames, Iowa, United States, 50011
Actively Recruiting
2
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
S
Susan J Persky, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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