Actively Recruiting
Cyclin D1 Based TPF Induction Chemotherapy for Oral Squamous Cell Carcinoma Patients at Clinical N2 Stage
Led by Shanghai Jiao Tong University School of Medicine · Updated on 2023-11-22
48
Participants Needed
1
Research Sites
521 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to To confirm the predictive value of CCND1 for TPF induction in cN2 patients with OSCC
CONDITIONS
Official Title
Cyclin D1 Based TPF Induction Chemotherapy for Oral Squamous Cell Carcinoma Patients at Clinical N2 Stage
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 75 years old
- Male or female sex
- Karnofsky performance status greater than 60
- Confirmed squamous cell carcinoma of the oral cavity by biopsy
- High expression of cyclin D1 protein
- Clinical stage III or IVA with resectable lesions
- Adequate blood counts: white blood cell count above 3,000/mm3, hemoglobin above 8 g/L, platelet count above 80,000/mm3
- Liver function with ALAT/ASAT less than 2.5 times upper normal limit and bilirubin less than 1.5 times upper normal limit
- Kidney function with serum creatinine less than 1.5 times upper normal limit
- Signed informed consent provided
You will not qualify if you...
- Presence of distant metastatic disease or other cancers
- Prior surgery on primary tumors or lymph nodes other than biopsy
- Previous radiotherapy or chemotherapy
- Other cancers diagnosed within the last 5 years
- Severe lung or heart diseases preventing treatment
- Legal incapacity or limited legal capacity
- Creatinine clearance less than 30 ml/min
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China, 200011
Actively Recruiting
Research Team
L
Lai-pimg Zhong, PHD
CONTACT
Y
Ying Liu, MPhil
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here