Actively Recruiting
Evaluating a Cycling-Based Aerobic Exercise Program for Chemotherapy-Induced Peripheral Neuropathy: A Proof-of-Concept Study
Led by University of Alberta · Updated on 2026-03-12
30
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
Sponsors
U
University of Alberta
Lead Sponsor
C
Cross Cancer Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating whether a stationary cycling-based aerobic exercise program can help reduce symptoms and improve function in individuals with chemotherapy-induced peripheral neuropathy (CIPN). This proof-of-concept study aims to assess the feasibility and acceptability of this exercise intervention by recruiting 30 participants with cancer who are either undergoing or have completed chemotherapy. The study will explore both patient-reported and objective outcomes related to CIPN, fitness, and quality of life. Participants will take part in a 12-week supervised aerobic exercise program involving stationary cycling sessions twice a week. Each week includes two types of sessions: continuous cycling and high-intensity interval training (HIIT), tailored to each participant's fitness level based on baseline heart rate testing. Certified exercise physiologists will supervise small groups of participants during sessions lasting between 30 and 60 minutes. During the study, researchers will monitor recruitment rates, participant adherence, program satisfaction, and safety, alongside measuring CIPN symptoms and fitness changes through questionnaires and clinical assessments. Participants will complete assessments before and after the intervention, with data analyzed to guide future larger trials. The total participation time spans 12 weeks of exercise sessions plus assessments, with safety and satisfaction carefully tracked throughout.
CONDITIONS
Brief Title
Cycling-Based Aerobic Exercise Intervention for Individuals With Chemotherapy-Induced Peripheral Neuropathy (CIPN)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years or older
- Diagnosed with cancer stage I to III
- Mild chemotherapy-induced peripheral neuropathy (grade 1)
- Currently receiving or have completed chemotherapy treatment
- Able to speak, read, and understand English
You will not qualify if you...
- Medical conditions that cause additional neuropathy symptoms, such as diabetes
- Any uncontrolled medical conditions
- Scheduled for surgery or radiation therapy during the study
- Currently participating in an aerobic exercise training program
- Enrolled in another exercise-based research study
- Unable to provide signed informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 weeks
Participants engage in a supervised 12-week cycling-based aerobic exercise program with twice weekly in-person exercise sessions supervised by qualified professionals.
Twice weekly in-person exercise sessions
Trial Site Locations
Total: 1 location
1
Cross Cancer Institute
Edmonton, Alberta, Canada, T6G 1Z2
Actively Recruiting
Research Team
C
Christopher Sellar, PhD
T
Trei Lindstrom, BSc
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
1
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