Actively Recruiting
Cytapheresis of Volunteer Donors
Led by National Institute on Aging (NIA) · Updated on 2026-05-01
10000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: \- National Institute on Aging researchers are looking at studies that require large numbers of white blood cells for lab use. Standard blood samples do not provide enough white blood cells for these studies. Researchers want to use cytapheresis to collect white blood cells from volunteer donors. This procedure can collect larger amounts of white blood cells and reduce the amount of fluid and other cells that are lost. Objectives: \- To use cytapheresis to collect white blood cells for study. Eligibility: \- Healthy blood donors at least 18 years of age. Design: * Participants will be screened according to the usual blood donation procedures. * Participants will provide white blood cells through cytapheresis. The blood cells will be collected in a machine that separates the white blood cells from the rest of the blood. The rest of the blood will be returned to the donor. * Participants may have this type of donation every 56 days (six times per year). They will be asked to become a repeat donor. A donation schedule may be set up. * Once a year, participants will have blood tests to continue to be eligible as a donor.
CONDITIONS
Official Title
Cytapheresis of Volunteer Donors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy males and females aged 18 years and older
- Adequate venous access in both upper arms to accommodate at least an 18 gauge dialysis needle
- Willingness and ability to visit the NIA Apheresis Unit at Harbor Hospital in Baltimore approximately every 56 days for blood collection
You will not qualify if you...
- Unable to provide valid identification with state ID, driver's license, or military ID
- Unable to give informed consent
- Weigh less than 110 pounds
- Taking chronic immunosuppressive medications such as steroids or Cellcept (steroids for minor illness ok if stopped more than 6 weeks before donation)
- Positive test results for HIV, Hepatitis B or C, or syphilis
- Ongoing risk factors for HIV or Hepatitis B or C (including intravenous drug use and non-monogamous unprotected sex)
- Risk factors for Creutzfeldt-Jakob disease (family history, certain hormone treatments, or travel to high-risk countries)
- Major medical illnesses including cancer, diabetes, deep vein thrombosis, organ or bone marrow transplant, or liver, kidney, heart, or lung disease
- Medical conditions that make the procedure unsafe (such as Parkinson's disease or dementia)
- Major infectious diseases like Chagas disease, babesiosis, or malaria
- Bleeding disorders such as hemophilia or von Willebrand's disease
- Abnormal blood test results such as elevated liver enzymes or abnormal kidney function
- Taking medications that affect white blood cell function such as chemotherapy or antivirals
- Pregnant or nursing mothers (temporary deferral for 6 weeks postpartum or after lactation cessation)
- Recent use of certain medications or vaccines (various deferral periods apply)
- Recent infection, fever, surgery, or exposure to bloodborne infections (deferral periods apply)
- Anemia or low blood counts below specified thresholds
- Recent blood donations or transfusions (deferral periods apply)
- Participation in incompatible research studies within 6 weeks
- Recent travel or residence in malaria-endemic countries with deferral periods based on duration and timing
AI-Screening
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Trial Site Locations
Total: 1 location
1
National Institute of Aging, Clinical Research Unit
Baltimore, Maryland, United States, 21224
Actively Recruiting
Research Team
L
Linda M Zukley, Ph.D.
CONTACT
C
Chee W Chia, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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