Actively Recruiting
Cytokine Response to Abdominal Wall Reconstruction
Led by Northwestern University · Updated on 2026-02-20
25
Participants Needed
1
Research Sites
56 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective, observational translational study of patients undergoing major abdominal wall reconstruction with primary fascial closure. The project integrates perioperative cytokine profiling, direct measurement of intra-abdominal pressure, and detailed clinical outcomes to define the biologic and physiologic consequences of high-tension closure. The study includes three cohorts: 1) Healthy controls (N=5), 2) High-tension fascial closure AWR patients (N=10), 3) Low-tension fascial closure AWR patients (N=10). Fascial closure tension will not be altered for the purpose of the study and will be determined by the operating surgeon as part of routine clinical decision-making.
CONDITIONS
Official Title
Cytokine Response to Abdominal Wall Reconstruction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Scheduled to undergo open retromuscular ventral hernia repair
- Able to provide written informed consent
- Adults aged 18 years or older (healthy controls)
- No known inflammatory, autoimmune, or immunologic disease (healthy controls)
- Able to provide written informed consent (healthy controls)
You will not qualify if you...
- Emergent or urgent cases
- Pregnancy
- Chronic systemic steroid use or immunosuppressive therapy
- Active infection at the time of enrollment
- Known autoimmune or inflammatory disease
- End-stage organ failure
- Abdominal surgery within the preceding 60 days
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Northwestern Memorial Hospital
Chicago, Illinois, United States, 60611
Actively Recruiting
Research Team
M
Megan Melland-Smith, MD
CONTACT
N
Nancy Ly, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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