Actively Recruiting

All Genders
ID05146336

CytOSorb TreatMent Of Critically Ill PatientS Registry: International Registry on the Use of CytoSorb in the Critical Care Setting

Led by CytoSorbents, Inc · Updated on 2025-09-11

3000

Participants Needed

28

Research Sites

13 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This observational registry studies the use of the CytoSorb device, a sorbent hemoperfusion system, in real-world critical care settings for patients with serious conditions such as septic shock, acute respiratory distress syndrome, trauma, and other life-threatening illnesses. The goal is to create a comprehensive data repository and reporting system to monitor and improve patient care quality when using this device in intensive care units. Participants will be those who have planned or actual use of the CytoSorb 300 mL device. The study collects data on the device's use without assigning specific treatments, serving as a scientific resource to evaluate outcomes like ICU and hospital mortality. This registry includes patients receiving the device in various critical care scenarios, excluding certain uses like antithrombotic removal or intraoperative cardiac surgery applications. During the study, data about patient outcomes through ICU discharge or hospital discharge will be collected and analyzed, typically over an average of 7 to 14 days. This includes monitoring ICU mortality and in-hospital mortality. The registry aims to support ongoing assessment of the device's use by gathering real-world patient information over time to help improve care practices in critical care environments.

CONDITIONS

Brief Title

CytOSorb TreatMent Of Critically Ill PatientS Registry

Who Can Participate

All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Planned or actual use of the CytoSorb 300 mL device
  • Informed consent provided for participation in the prospective registry
Not Eligible

You will not qualify if you...

  • Use of the CytoSorb 300 mL device only for antithrombotic removal
  • Use of the CytoSorb 300 mL device only during cardiac surgery intraoperatively
  • Occurrence of complications or medical reasons after consent that contraindicate or make CytoSorb use inappropriate

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Implementation

Duration - Approximately 7 to 14 days

Participants receive treatment with the CytoSorb sorbent hemoperfusion system as part of routine critical care.

Visits during ICU and hospital stay as per routine care

Long-term Monitoring

Duration - Up to hospital discharge

Participants are observed for outcomes including ICU and in-hospital mortality after treatment with CytoSorb.

Follow-up visits during hospital stay as needed

Trial Site Locations

Total: 28 locations

1

Klinikum Klagenfurt am Wörthersee

Klagenfurt, Austria, 9020

Actively Recruiting

2

Medizinische Universität Wien

Vienna, Austria, 1090

Actively Recruiting

3

Universitätsklinikum Aachen

Aachen, Germany, 52074

Actively Recruiting

4

Herz- und Diabeteszentrum Nordrhein-Westfalen

Bad Oeynhausen, Germany, 32545

Actively Recruiting

5

Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil Bochum

Bochum, Germany, 44789

Actively Recruiting

6

Katholisches Klinikum Bochum, St. Josef-Hospital

Bochum, Germany, 44791

Actively Recruiting

7

Universitätsklinikum Essen, Medizinische Intensivtherapie

Essen, Germany, 45147

Actively Recruiting

8

Universitätsklinikum Essen, Nephrologie

Essen, Germany, 45147

Actively Recruiting

9

Universitätsklinikum Essen, Thorax- und Kardiovaskuläre Chirurgie

Essen, Germany, 45147

Actively Recruiting

10

Universitätsmedizin Göttingen, Allgemein-, Viszeral- und Kinderchirurgie

Göttingen, Germany, 37075

Actively Recruiting

11

Universitätsmedizin Göttingen, Herzzentrum Göttingen

Göttingen, Germany, 37075

Actively Recruiting

12

Klinikum Herford

Herford, Germany, 32049

Actively Recruiting

13

Universitätsklinikum Jena

Jena, Germany, 07747

Actively Recruiting

14

Klinikum Kassel

Kassel, Germany, 34125

Withdrawn

15

Universitätsklinikum Marburg

Marburg, Germany, 35043

Actively Recruiting

16

Kliniken Maria Hilf

Mönchengladbach, Germany, 41063

Terminated

17

Deutsches Herzzentrum München

München, Germany, 80636

Actively Recruiting

18

LMU Klinikum München

München, Germany

Actively Recruiting

19

Klinikum Oldenburg

Oldenburg, Germany, 26133

Actively Recruiting

20

Helios Dr. Horst Schmidt Kliniken Wiesbaden

Wiesbaden, Germany, 65199

Actively Recruiting

21

Ospedale Pediatrico Bambino Gesù

Roma, Italy, 00165

Terminated

22

IRCCS Ospedale Casa Sollievo della Sofferenza

San Giovanni Rotondo, Italy, 71013

Actively Recruiting

23

SP ZOZ Szpital Uniwersytecki w Krakowie

Krakow, Poland, 30-688

Actively Recruiting

24

Uniwersyteckim Spitalem Klinicznym im. Jana Mikulicza - Radeckiego we Wrocławiu

Wroclaw, Poland, 50-556

Actively Recruiting

25

Unidade Local de Saúde de Coimbra E.P.E

Coimbra, Portugal, 3004-561

Actively Recruiting

26

ULS São José, Hospital Curry Cabral

Lisbon, Portugal

Actively Recruiting

27

Hospital Universitari Vall d'Hebron

Barcelona, Barcelona, Spain, 08035

Actively Recruiting

28

Hospital Juan Ramón Jimenez

Huelva, Spain

Actively Recruiting

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Research Team

R

Robert Wilke

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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Published Research Related To This Trial

The international, prospective CytOSorbⓇ treatMent Of critically ill patientS (COSMOS) registry: Interim results from the first 150 patients.

Ricard Ferrer, Matthias Thielmann, Andreas Kribben...

https://pubmed.ncbi.nlm.nih.gov/41180104

The COSMOS Registry of CytoSorb Hemoadsorption Therapy in Critically Ill Patients: Protocol for an International, Prospective Registry.

Fabio Silvio Taccone, Frank Martin Brunkhorst, Gabriella Bottari...

https://pubmed.ncbi.nlm.nih.gov/39500494