The COSMOS Registry of CytoSorb Hemoadsorption Therapy in Critically Ill Patients: Protocol for an International, Prospective Registry.
Fabio Silvio Taccone, Frank Martin Brunkhorst, Gabriella Bottari...
https://pubmed.ncbi.nlm.nih.gov/39500494/Actively Recruiting
Led by CytoSorbents, Inc · Updated on 2025-09-11
3000
Participants Needed
28
Research Sites
13 weeks
Total Duration
This observational registry studies the use of the CytoSorb device, a sorbent hemoperfusion system, in real-world critical care settings for patients with serious conditions such as septic shock, acute respiratory distress syndrome, trauma, and other life-threatening illnesses. The goal is to create a comprehensive data repository and reporting system to monitor and improve patient care quality when using this device in intensive care units. Participants will be those who have planned or actual use of the CytoSorb 300 mL device. The study collects data on the devices use without assigning specific treatments, serving as a scientific resource to evaluate outcomes like ICU and hospital mortality. This registry includes patients receiving the device in various critical care scenarios, excluding certain uses like antithrombotic removal or intraoperative cardiac surgery applications. During the study, data about patient outcomes through ICU discharge or hospital discharge will be collected and analyzed, typically over an average of 7 to 14 days. This includes monitoring ICU mortality and in-hospital mortality. The registry aims to support ongoing assessment of the devices use by gathering real-world patient information over time to help improve care practices in critical care environments.
CONDITIONS
CytOSorb TreatMent Of Critically Ill PatientS Registry
R
Robert Wilke
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
CytoSorbents, Inc
Lead Sponsor
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 7 to 14 days
Participants receive treatment with the CytoSorb sorbent hemoperfusion system as part of routine critical care.
Visits during ICU and hospital stay as per routine care
Duration - Up to hospital discharge
Participants are observed for outcomes including ICU and in-hospital mortality after treatment with CytoSorb.
Follow-up visits during hospital stay as needed
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Have more questions? Get in touch with our team for quick support
Fabio Silvio Taccone, Frank Martin Brunkhorst, Gabriella Bottari...
https://pubmed.ncbi.nlm.nih.gov/39500494/Ricard Ferrer, Matthias Thielmann, Andreas Kribben...
https://pubmed.ncbi.nlm.nih.gov/41180104/CytoSorbents, Inc
Lead Sponsor