Actively Recruiting
d-Limonene +Radiation +PlatinumBasedChemo for Xerostomia Prevention in LocallyAdvanced HNSCC
Led by Stanford University · Updated on 2025-07-20
40
Participants Needed
1
Research Sites
378 weeks
Total Duration
On this page
Sponsors
S
Stanford University
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study explores the safety of d-limonene, a commercially-available dietary supplement (food) as a potential therapeutic for the severe dry mouth (xerostomia) experienced by patients with head and neck cancer as a side effect of their anti-cancer treatment.
CONDITIONS
Official Title
d-Limonene +Radiation +PlatinumBasedChemo for Xerostomia Prevention in LocallyAdvanced HNSCC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically or cytologically confirmed advanced loco regional squamous cell carcinoma of the nasopharynx, oropharynx, larynx, or hypopharynx, or head and neck squamous cell carcinoma from unknown primary with involved nodes
- Scheduled for definitive radiation therapy with concurrent platinum based chemotherapy at Stanford
- Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1
- Able to swallow d-limonene gelcaps at enrollment
- Adequate liver function within 2 weeks prior to registration: Bilirubin 2 mg/dL; AST or ALT < 3 times upper limit of normal
- Adequate blood counts within 2 weeks prior: ANC 1,500/mm3; platelets 100,000/mm3; hemoglobin 8.0 g/dL (transfusion allowed to achieve this)
- Adequate kidney function within 2 weeks prior: Serum creatinine 1.5 mg/dL or creatinine clearance 50 mL/min
- Negative pregnancy test within 2 weeks prior and agreement to use birth control during d-limonene treatment for women of childbearing potential
- Able to understand and willing to sign informed consent
You will not qualify if you...
- History of allergic reactions to citrus fruits
- Pregnant or lactating
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Stanford University
Stanford, California, United States, 94305
Actively Recruiting
Research Team
C
Camellia Djebroun
CONTACT
K
Kelly Huang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
7
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here