Actively Recruiting
D3-Creatine and Skeletal Muscle in Older Adults
Led by McMaster University · Updated on 2024-10-08
350
Participants Needed
1
Research Sites
195 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The age-related decline in muscle mass and strength are collectively referred to as sarcopenia. However, the tools currently employed to assess skeletal muscle mass (SMM) (e.g., Dual-energy Xray Absorptiometry; DXA) have substantial drawbacks, and it is known that DXA-lean soft tissue (LST) is generally not associated with health outcomes of interest. Thus, the investigators propose using a novel, non-invasive, stable isotope-labelled probe (Deuterium (D)-labelled creatine (D3-creatine; D3-Cr)) to measure skeletal muscle mass in a large cohort of older individuals. The development and employment of new methods to accurately quantify the biological substrate of sarcopenia, skeletal muscle, are critical for the measure to remain clinically relevant. The plan is to measure 350 persons from the recently established (M3) prospective cohort. There will be measurement of lean soft tissue LST and appendicular LST (aLST) using DXA and compared to D3-Cr-measured SMM (D3-Cr-SMM) at baseline, 12mo, and 24mo (2yr) of follow-up. Physical mobility will also be measured (using various instruments).
CONDITIONS
Official Title
D3-Creatine and Skeletal Muscle in Older Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between 60 and 80 years old (inclusive)
- Reside within 60 kilometers of Hamilton, Canada
- Willing and able to provide written informed consent
- Self-reported no difficulty, early difficulty with task modification, or minor difficulty walking 800 meters
- Self-reported no difficulty, early difficulty with task modification, or minor difficulty climbing ten steps
- Self-reported no difficulty, early difficulty with task modification, or minor difficulty transferring from or into a car or bus
You will not qualify if you...
- Self-reported more than minor difficulty walking 800 meters, climbing ten steps, or transferring from or into a car or bus (considered mobility disability)
- Cannot speak or read English
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Exercise Metabolism Research Laboratory, McMaster Univeristy
Hamilton, Ontario, Canada, L8S 4K1
Actively Recruiting
Research Team
S
Shalini Jaisankar Sumathi, MS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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