Adaptive Daily External Beam Radiation Therapy Using Varian Ethos for Advanced Cervical Cancer A Prospective Study to Reduce Intestinal Side Effects During Treatment

What this Trial Is About

Researchers are evaluating a new approach called adaptive radiotherapy for women with locally advanced cervical cancer. This study aims to see if this personalized radiation treatment can reduce the rate of acute gastrointestinal side effects compared to the usual radiation method called intensity modulated radiation therapy IMRT. The main focus is on side effects reported by patients during the fifth week of external beam radiotherapy. Participants will receive daily adaptive external beam radiation therapy using the Varian Ethos treatment system. This treatment adjusts to individual patient anatomy each day to potentially minimize side effects. The study is single-arm and involves multiple centers. Treatment and assessments occur through the external beam radiotherapy period, with no control group. The primary evaluation happens at week 5 of treatment. During the study, participants will complete questionnaires about symptoms and quality of life, including PRO-CTCAE, EQ-5D, EPIC, and EORTC tools. Researchers will monitor bowel and urinary side effects, quality of life up to 24 months after treatment, disease-free survival, and treatment feasibility. Safety and normal tissue complications will be tracked through two years. Participants are expected to attend study visits and complete patient-reported outcomes during and after treatment.

Daily Adaptive Radiation Therapy an Individualized Approach for Carcinoma of the Cervix