Effects of Targeted Amino Acid Supplementation for People With Parkinsons Disease on Amino Acid Profiles and Health Related Markers

What this Trial Is About

Researchers are investigating whether a specially designed amino acid supplement can help adults with Parkinsons disease improve their nutrition, metabolism, body composition, and physical and mental health. The study aims to see if this tailored supplement increases key essential amino acids and antioxidants, reduces harmful amino acids linked to oxidative stress, and improves overall health compared to a placebo. The trial focuses on people aged 60 to 80 years who have Parkinsons disease and are on stable dopamine replacement therapy. Participants will be randomly assigned to take either the targeted amino acid supplement or an inactive placebo containing alanine daily for six months. The supplement includes a blend of essential, conditionally essential, and non-essential amino acids chosen to meet the unique nutritional needs of people with Parkinsons disease. The study is designed as a quadruple-blind trial, meaning neither participants nor researchers know who receives the supplement or placebo during the study. During the trial, participants will visit the lab at the start, after three months, and after six months for fasting blood tests to measure amino acid levels and oxidative stress. Their body composition will be assessed using bioelectrical impedance and ultrasound techniques. Physical function tests such as balance, walking speed, strength, and grip will be conducted, along with questionnaires on quality of life, fatigue, sleep, mood, anxiety, motivation, and depression. Physical activity will be monitored before and after the study, and insulin sensitivity will also be evaluated. Participants will keep diaries of their food and supplement intake throughout the six months.

Daily Amino Acid Supplementation for People With Parkinson's Disease