Actively Recruiting
Daily Amino Acid Supplementation for People With Parkinson's Disease
Led by Cristina Colon-Semenza · Updated on 2025-11-13
30
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
Sponsors
C
Cristina Colon-Semenza
Lead Sponsor
U
United States Department of Agriculture (USDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if a tailored amino acid supplement works to help adults living with Parkinson's disease to improve nutrition, metabolic function, body composition, and physical and mental function. The main questions it aims to answer are: Does the tailored amino acid supplement increase essential amino acids (nutritional status)? Does the tailored amino acid supplement increase an antioxidant (complex amino acid) and decrease an amino acid associated with oxidative stress? Does the tailored amino acid supplement improve physical and mental health compared to a placebo supplement? Researchers will compare the tailored amino acid supplement to a placebo (a look-alike substance that contains no active ingredients) to see if the tailored amino acid supplements work to support health for people with Parkinson's disease. Participants will: Take the tailored amino acid supplement or a placebo every day for 6 months, visit the lab at baseline, after 3 months, and after 6 months for fasting blood draws, body composition assessment, and physical and mental health testing and keep a diary of their food intake and supplement intake.
CONDITIONS
Official Title
Daily Amino Acid Supplementation for People With Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and females
- Aged between 60 and 80 years
- Previous diagnosis of idiopathic Parkinson's disease by patient report
- Use of dopamine replacement medication (e.g., levodopa) for at least 2 years
- On a stable dose of dopamine replacement medication for at least 3 months with no planned changes in the next two months
You will not qualify if you...
- Apparent cognitive impairment as determined by phone screening (Telephone Interview for Cognitive Status <29)
- Diagnosis of Parkinsonism or atypical Parkinson's disease
- Prescription of dopamine antagonist
- Any unstable medical condition
- Known bleeding disorder or current use of blood thinners
- Use of Deep Brain Stimulation
- History of gastric or bowel resection surgery
- Contraindications to blood draw
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Connecticut
Storrs, Connecticut, United States, 06269
Actively Recruiting
Research Team
C
Carlos Rehbein, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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