Effects of a Targeted Amino Acid Supplement on Health and Amino Acid Levels in Adults with Parkinsons Disease Ages 50 to 80

What this Trial Is About

Researchers are evaluating the effects of a targeted amino acid supplement designed to meet the unique nutritional needs of adults living with Parkinsons disease PD. This study aims to understand whether this supplement can improve amino acid levels, metabolic function, body composition, physical abilities, and mental health. The study compares the tailored amino acid supplement to a placebo to see if it supports better health outcomes in people with PD. Participants will be randomly assigned to receive either the targeted amino acid blend, which includes essential, conditionally essential, and non-essential amino acids, or a placebo containing an inert amino acid. They will take the assigned supplement daily for six months. The study involves a parallel design with visits at the start, after three months, and at the six-month mark. During the study, participants will visit the lab three times for fasting blood tests, body composition measurements using bioelectrical impedance and ultrasound, and assessments of physical function like balance, gait speed, strength, and self-reported outcomes such as quality of life, fatigue, sleep, mood, anxiety, motivation, and depression. Researchers will monitor amino acid bioavailability, oxidative stress, insulin sensitivity, and other health markers. Participants will also keep a diary of their food and supplement intake throughout the study.

Daily Amino Acid Supplementation for People With Parkinson's Disease