Actively Recruiting
Daily Hand-Held Vibration Therapy
Led by Indiana University · Updated on 2026-02-06
16
Participants Needed
3
Research Sites
242 weeks
Total Duration
On this page
Sponsors
I
Indiana University
Lead Sponsor
I
Indiana Clinical and Translational Sciences Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this pilot study is to determine the safety and feasibility of a daily 3-minute hand-held vibration therapy intervention to reduce the severity of CIPN in the hands. The investigators hypothesize that daily vibration therapy can reduce the severity of patient's CIPN in their hands and improve CIPN-related quality of life. The hope is that results from this study will provide early data on the feasibility, efficacy, and most importantly, safety, of daily 3-minute hand-held vibration therapy needed to justify future clinical trials examining vibration therapy as a potential option for treating CIPN in the future.
CONDITIONS
Official Title
Daily Hand-Held Vibration Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years or older at enrollment
- Able to provide informed consent and HIPAA authorization
- Completed chemotherapy at least 60 days before enrollment
- Exposure to neurotoxic chemotherapy with specified agents and doses: Paclitaxel (≥ 300 mg/m2), Docetaxel (≥ 100 mg/m2), Nab-paclitaxel (≥ 750 mg/m2), Oxaliplatin (≥ 510 mg/m2), Carboplatin (≥ 600 mg/m2), Cisplatin (≥ 200 mg/m2), Vincristine (≥ 4 mg/m2), Bortezomib (≥ 16 mg/m)
- Ongoing sensory CIPN in hands rated Grade ≥ 2 by NCI-CTC-AE Version 5.0 at least 60 days post-chemotherapy
- If solid tumor cancer, must be non-metastatic
- Agree to return to clinic for required study-related measurements
You will not qualify if you...
- Pre-existing neuropathy affecting hands not related to chemotherapy (e.g., carpal tunnel syndrome, nerve compression)
- Known diagnosis of diabetes mellitus
- Contraindications for hand vibration therapy, including deep venous thrombosis of upper extremity or ongoing skin infection
- Receiving concurrent radiation therapy to the upper extremity
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Indiana University Health West
Avon, Indiana, United States, 46123
Actively Recruiting
2
Indiana University Melvin & Bren Simon Cancer Center
Indianapolis, Indiana, United States, 46202
Actively Recruiting
3
IU Health Joe & Shelly Schwarz Cancer Center
Indianapolis, Indiana, United States, 46202
Actively Recruiting
Research Team
C
Ceri West
CONTACT
L
Lacy Slayton
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
1
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