Actively Recruiting
Daily Intake of Multivitamin & Mineral Supplementation Effects on Biological Age of Relatively Healthy Middle-aged Individuals
Led by National University of Singapore · Updated on 2024-10-30
400
Participants Needed
2
Research Sites
40 weeks
Total Duration
On this page
Sponsors
N
National University of Singapore
Lead Sponsor
H
HALEON
Collaborating Sponsor
AI-Summary
What this Trial Is About
Micronutrients, such as vitamins and minerals, are required to sustain fundamental physiological processes in individuals. As individuals age, the risk of having suboptimal levels of micronutrients increases due to several age-related changes affecting their digestion and assimilation processes. Suboptimal levels of micronutrients have been associated with increased risk of chronic diseases and accelerated ageing. Three years intake of a multivitamin and mineral supplement (MVM) improved global cognition, episodic memory and executive function in older adults. Furthermore, suboptimal micronutrient levels have been associated with a higher biological age, and diet and lifestyle interventions might lower the biological age measured by methylation clocks. Therefore, further evaluation is warranted to determine if MVM supplementation could improve the biological age and clinical outcomes in individuals with a higher biological age.
CONDITIONS
Official Title
Daily Intake of Multivitamin & Mineral Supplementation Effects on Biological Age of Relatively Healthy Middle-aged Individuals
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy men or women aged 40 to 60 years
- Completed pre-screening and scheduled screening visit
- Biological age higher than chronological age based on blood DNA methylation
- Able to attend all 4 research visits at the study site
- Willing to wear an OURA ring for 14 days after each study visit
- Willing to use the study app on their mobile phone throughout the study period
You will not qualify if you...
- Body mass index (BMI) below 18 kg/m2 or 30 kg/m2 and above
- History of major cardiovascular diseases or severe/uncontrolled hypertension
- Type 1 or Type 2 diabetes
- Active cancer or cancer treatment in the past 3 years
- Chronic obstructive pulmonary disease or severe asthma requiring daily medication
- Pregnant or planning pregnancy within 12 months
- Autoimmune or immune deficiency diseases such as rheumatoid arthritis, HIV, Crohn's disease
- Recent severe infections requiring hospitalisation within 3 months
- Psychiatric or neurodegenerative diseases including Alzheimer's, Parkinson's, Lewy body dementia
- Hepatitis or liver cirrhosis
- Severe kidney disease with low filtration rate
- Skin diseases treated with systemic medication
- Participation in other trials with similar supplements
- Advised by a doctor to take MVM supplements
- Refusal to stop non-prescribed supplements containing study ingredients
- Taking prescribed supplements with two or more study ingredients
- Planned hospitalization within 12 months
- Any serious medical illness that may affect study participation or completion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Healthy Longevity Translational Research Programme, Level 3, MD 11, 10 Medical Dr, Yong Loo Lin School of Medicine, National University of Singapore
Singapore, Singapore, Singapore, 117597
Actively Recruiting
2
Center for Healthy Longevity, Clinic L, Alexandra Hospital, 378 Alexandra Road
Singapore, Singapore, Singapore, 159964
Actively Recruiting
Research Team
A
Andrea Britta Maier, MD PhD FRACP
CONTACT
M
Muhammad Daniel Azlan Mahadzir, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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