Actively Recruiting
Daily Nitrofurantoin Versus Bladder Fulguration Plus Daily Nitrofurantoin for Women With Recurrent Urinary Tract Infections
Led by University of Texas Southwestern Medical Center · Updated on 2026-05-01
104
Participants Needed
2
Research Sites
147 weeks
Total Duration
On this page
Sponsors
U
University of Texas Southwestern Medical Center
Lead Sponsor
U
University of Texas
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if the drug Nitrofurantoin (NF) taken as a daily antibiotic, works to treat cystitis compared to electrofulguration (EF) and Nitrofurantoin (NF) daily antibiotic.
CONDITIONS
Official Title
Daily Nitrofurantoin Versus Bladder Fulguration Plus Daily Nitrofurantoin for Women With Recurrent Urinary Tract Infections
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female aged 18 to 85 years with a history of culture documented uncomplicated recurrent urinary tract infections for at least 1 year
- Diagnosis of recurrent urinary tract infections defined as at least 3 symptomatic UTIs in 12 months or at least 2 in 6 months
- Currently free from urinary tract infection symptoms and negative urine culture with less than 10^3 colony forming units per ml
- Negative upper and lower urinary tract evaluation including pelvic exam showing pelvic organ prolapse stage 2 or less, post-void residual less than 50 ml, and imaging excluding kidney stones, hydronephrosis, reflux, or urethral diverticulum
- Office cystoscopy showing stage 1 or 2 chronic cystitis
- Likely to remain in the geographic area for the study duration
- ASA physical status class II or less
You will not qualify if you...
- Use of antibiotics at baseline for suppressive therapy or non-urinary infections
- Use of self-start antibiotic therapy for urinary symptoms
- Use of prophylactic antibiotics started within the last 3 months and unwilling to stop, or plans to start in the next 12 months
- Complicated urinary tract infections including neurogenic bladder, bladder augmentation, or urinary diversion
- Presence of urinary catheters including indwelling Foley, intermittent catheterization, or suprapubic catheters
- Uncontrolled diabetes with HbA1c greater than 9
- Pregnancy
- Allergy or resistance to Nitrofurantoin
- Chronic lung or liver conditions preventing Nitrofurantoin use, including abnormal chest X-ray or elevated liver tests
- Chronic kidney insufficiency with creatinine over 1.5 g/dl or GFR less than 40
- History of chronic diarrhea requiring regular treatment
- Psychosis, dementia, swallowing disorders, or inability to take Nitrofurantoin reliably at home
- Body mass index over 40
- Use of Uromune or other vaccines to reduce recurrent urinary tract infections
- Participation in investigational research in the past 12 weeks
- Receiving phage therapy
- Current diagnosis of interstitial cystitis
- Medical conditions requiring excessive fluid intake
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
The University of Kansas
Kansas City, Kansas, United States, 66160
Not Yet Recruiting
2
UT Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
Research Team
M
Meghan Leak
CONTACT
P
Philippe Zimmern, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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