Bioactive Dairy Lipids to Manage Cardiometabolic Risk in Obesity

What this Trial Is About

Researchers are evaluating the effects of different types of dairy products on adults with severe obesity in this randomized study. The purpose is to see if daily consumption of whole dairy products enriched with milk polar lipids can reduce fasting plasma apolipoprotein B levels more than low-fat dairy products during a 3-month weight loss diet. This study focuses on cardiometabolic risk factors related to obesity. Participants are divided into three groups receiving different dairy product regimens for three months: low-fat dairy (cheese, yogurt, milk), whole-fat dairy, and whole-fat dairy enriched with milk polar lipids through butter. Each group consumes three servings daily as part of a dietary weight loss plan. The study compares these interventions to assess their impact on metabolic health. During the study, participants undergo assessments before and after the 3-month intervention, including fasting and post-meal blood tests to measure metabolic markers, body weight, body composition, and inflammation indicators. Questionnaires on physical activity, digestive comfort, satiety, food intake, and product appreciation are also completed. Researchers closely monitor changes in plasma lipid and glucose levels at multiple time points, as well as intestinal microbiota and immune cell markers, to understand the effects of these dairy products on cardiometabolic health.

Dairy Lipids and Cardiometabolic Risk