Actively Recruiting
Dairy Lipids and Cardiometabolic Risk
Led by Hospices Civils de Lyon · Updated on 2025-06-18
75
Participants Needed
2
Research Sites
170 weeks
Total Duration
On this page
Sponsors
H
Hospices Civils de Lyon
Lead Sponsor
L
Laboratoire de Recherche en Cardiovasculaire, Métabolisme, Diabétologie et Nutrition
Collaborating Sponsor
AI-Summary
What this Trial Is About
It is a randomized parallel arm intervention study in adults with severe obesity. The objective is to demonstrate that within a dietary handling for weight loss, the daily ingestion during 3 months of whole dairy products enriched with milk polar lipids or whole dairy products decreases to a greater extent fasting plasma apolipoprotein B concentrations than the daily ingestion of low-fat dairy products (control group). Metabolic parameters will be assessed before and after the 3-month intervention, both at fasting and in postprandial period after the consumption of standardized meals.
CONDITIONS
Official Title
Dairy Lipids and Cardiometabolic Risk
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women between 18-70 years
- Body Mass Index (BMI) between 35 and 60 kg/m2 inclusive
- Stable body weight (weight change +/- 5 % for 3 months prior to screening)
- Consumption of at least 1 serving/day of dairy products made from cow's milk
- Informed consent
You will not qualify if you...
- History of bariatric or digestive surgery or disease interfering with main outcomes
- Drinking more than 3 glasses of alcohol per day (>30g/day)
- Pregnancy, parturiency or breastfeeding
- Food allergies or intolerance to dairy products
- Dietary restriction (vegetarian or lactovegetarian) or high protein diet
- Use of dietary supplements
- Treated with lipid lowering drugs (fibrates, statins, anti-PCSK9, ezetimibe, cholestyramine) within the last 6 weeks before study entry
- Treated with insulin, GLP-1 analogs, acarbose, corticoids, beta-blockers
- Medications interfering with intestinal microbiota (beta-lactamines within 3 months before the study or laxatives)
- Smoking ≥ 5 cigarettes/day during the past 6 months.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Centre de Recherche en Nutrition Humaine Rhône-Alpes
Pierre-Bénite, France, 69310
Active, Not Recruiting
2
Centres Hospitalier Lyon Sud, Service d'Endocrinologie-Diabète-Nutrition
Pierre-Bénite, France, 69310
Actively Recruiting
Research Team
E
Emmanuel DISSE, Pr
CONTACT
M
MArie-Caroline MICHALSKI, Dr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
3
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