Study on Ovarian Tissue Freezing to Improve Fertility in Girls with Turner Syndrome Aged 2 to 17

What this Trial Is About

This research aims to explore whether freezing ovarian tissue in girls with Turner syndrome can help improve their fertility and increase the chances of having liveborn children. Turner syndrome often causes early ovarian failure leading to infertility and low estrogen levels. The study also investigates if hormone monitoring can predict menopause timing in these girls and looks for genes that may cause ovarian failure in Turner syndrome. Participants between 2 and 18 years old will undergo laparoscopic surgery to remove one ovary, which will be frozen until they reach adulthood. Later, the ovarian tissue will be transplanted back to preserve fertility. The study includes monitoring sex hormones during the study period and analyzing the ovarian tissue through advanced genetic and molecular techniques. There is no comparison group in this trial. During the study, participants will have physical and cardiac examinations and hormone level checks. Researchers will measure pregnancy rates, number of liveborn children, ovarian follicles soon after surgery, and track predictors of ovarian failure over many years. Additional assessments include gene expression, DNA methylation, uterine growth, bone health, and quality of life. The trial may last decades, with careful long-term monitoring to understand the impact of the treatment.

The Danish TURNER Cryopreservation Study