Actively Recruiting
DAOIB for the Treatment of Brain Fog
Led by Chang Gung Memorial Hospital · Updated on 2026-03-19
40
Participants Needed
1
Research Sites
170 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a 24-week open trial. We will enroll long-COVID patients with cognitive impairments. All patients will receive DAOIB for 24 weeks. We will assess the patients every 8 weeks during the treatment period (weeks 0, 8, 16, and 24). We hypothesize that DAOIB treatment will be beneficial in improving the cognitive function, mood symptoms, global functioning and quality of life in long-COVID patients with cognitive impairments.
CONDITIONS
Official Title
DAOIB for the Treatment of Brain Fog
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Post-COVID-19 condition defined by WHO with symptoms present at three months after SARS-CoV-2 infection lasting at least 2 months, including COVID-induced cognitive impairments
- Physically healthy with all laboratory assessments (urine/blood routine, biochemical tests, and electrocardiograph) within normal limits
- Sufficient education to communicate effectively and able to complete study assessments
You will not qualify if you...
- History of significant cerebrovascular disease
- Hachinski Ischemic Score greater than 4
- Major neurological, psychiatric, or medical conditions other than long COVID-induced cognitive impairments
- Current use of memantine (an NMDAR partial antagonist)
- Substance (including alcohol) abuse or dependence
- Presence of delusion, hallucination, or delirium symptoms
- Severe visual or hearing loss
- Inability to follow the study protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, Taiwan, 886
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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