Actively Recruiting
Daptomycin vs. Vancomycin for the Treatment of Methicillin Resistant S. Aureus Bacteremia
Led by Todd C. Lee MD MPH FIDSA · Updated on 2026-05-07
300
Participants Needed
15
Research Sites
154 weeks
Total Duration
On this page
Sponsors
T
Todd C. Lee MD MPH FIDSA
Lead Sponsor
U
University of Melbourne
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is an open label randomized controlled trial for patients with methicillin resistant S. aureus (MRSA) bloodstream infection which will directly compare the two most commonly used therapies, vancomycin and daptomycin. This study is an approved sub-study of The Staphylococcus aureus Network Adaptive Platform (SNAP) trial (NCT05137119)
CONDITIONS
Official Title
Daptomycin vs. Vancomycin for the Treatment of Methicillin Resistant S. Aureus Bacteremia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Methicillin-resistant Staphylococcus aureus bacteremia
You will not qualify if you...
- Severe allergy or non-severe rash to vancomycin or daptomycin
- Suspected or confirmed MRSA pneumonia
- Known vancomycin minimum inhibitory concentration (MIC) greater than or equal to 2mg/L or daptomycin MIC greater than or equal to 1mg/L
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 15 locations
1
Concord Repatriation and General Hospital
Concord, New South Wales, Australia, 2139
Actively Recruiting
2
John Hunter Hospital
Newcastle, New South Wales, Australia, 2305
Actively Recruiting
3
Westmead Hospital
Westmead, New South Wales, Australia, 2145
Actively Recruiting
4
Royal Brisbane and Women's Hospital
Herston, Queensland, Australia, 4029
Actively Recruiting
5
Flinders Medical Centre
Bedford Park, South Australia, Australia, 5042
Actively Recruiting
6
Box Hill Hospital
Box Hill, Victoria, Australia, 3128
Actively Recruiting
7
Monash Medical Campus (Monash Medical Centre + Jesse McPherson Private Hospital)
Clayton, Victoria, Australia, 3168
Actively Recruiting
8
Royal Melbourne Hospital
Parkville, Victoria, Australia, 3050
Actively Recruiting
9
Fiona Stanley Hospital
Murdoch, Western Australia, Australia, 6150
Actively Recruiting
10
Royal Perth Hospital
Perth, Western Australia, Australia, 6000
Actively Recruiting
11
University of Alberta Hospital
Edmonton, Alberta, Canada
Actively Recruiting
12
Fraser Health Authority (Surrey Memorial Hospital)
Surrey, British Columbia, Canada, V3V1Z2
Actively Recruiting
13
Newfoundland Health Services (Health Sciences Centre and St. Clare's Mercy Hospital)
St. John's, Newfoundland and Labrador, Canada
Actively Recruiting
14
Hamilton Health Sciences (Hamilton General Hospital and Juravinski Hospital)
Hamilton, Ontario, Canada, L8L 2X2
Actively Recruiting
15
McGill University Health Centre (Royal Victoria Hospital and Montreal General Hospital)
Montreal, Quebec, Canada, H4A3S1
Actively Recruiting
Research Team
L
Lina Petrella
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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