Actively Recruiting
Dark Adaptation as an Early Indicator of Response to Statin Therapy for Intermediate AMD
Led by Massachusetts Eye and Ear Infirmary · Updated on 2026-01-26
21
Participants Needed
1
Research Sites
360 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
interventional trial for off label use of high dose atorvastatin 80 mg in intermediate AMD patients and correlate recovery response measured by dark adaptation recovery time with drusen volume reduction measured by SD-OCT
CONDITIONS
Official Title
Dark Adaptation as an Early Indicator of Response to Statin Therapy for Intermediate AMD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- All subjects with intermediate AMD diagnosis in one or both eyes, regardless of severity stage or subtype in the other eye
- Presence of high-risk intermediate AMD with numerous large, confluent drusen covering 60.5 disk area, with or without pigmentary changes, but no geographic atrophy or choroidal neovascularization in the study eye
- Subjects may have either bilateral high-risk intermediate AMD or high-risk intermediate AMD in one eye with geographic atrophy and/or choroidal neovascularization in the other eye
- Age between 50 and 85 years
You will not qualify if you...
- Previous use of high-dose atorvastatin (80 mg)
- Previous use of other statins if primary care provider feels patient cannot be safely switched to high-dose atorvastatin or if high-dose atorvastatin is contraindicated
- Known adverse reaction to statins
- Severe renal disease or multiple comorbidities
- Age over 85 years
- Pregnancy
- Use of cyclosporine
- Active uveitis
- Ocular infection
- Any retinopathy other than AMD
- Media opacities affecting the eye
- Refractive error equal to or greater than 6 diopters (spherical equivalent)
- History of retina surgery
- Other ocular surgery or intraocular procedures (except anti-angiogenic injections or laser) in the study eye within 90 days before enrollment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Massachusetts Eye and Ear Infirmary
Boston, Massachusetts, United States, 02114
Actively Recruiting
Research Team
J
John B Miller, MD
CONTACT
D
Deeba Husain
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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