Collecting Data on Side Effects and Tissue Responses in Adults Receiving Proton Therapy for Cancer

What this Trial Is About

Researchers are collecting detailed information on side effects and treatment plans of proton therapy in patients with various types of cancer, including breast, esophageal, genitourinary, head and neck, hematopoietic and lymphoid cell neoplasms, lung, malignant central nervous system, digestive system, and other solid tumors. This observational study aims to help predict risks and understand the long-term effects of proton therapy on normal tissues. Patients receiving standard proton therapy as part of their usual care are monitored weekly for side effects during treatment, then one to three times within 90 days after treatment starts, and annually thereafter. They also complete questionnaires about their symptoms and quality of life at baseline, weekly during treatment, and every two weeks for up to three months after therapy. Participants are actively involved by completing symptom questionnaires and undergoing regular toxicity assessments. Researchers collect data on acute and late toxicities, including second malignant neoplasms, and correlate these with radiation dose distributions and imaging. The study measures symptom burden using the M.D. Anderson Symptom Inventory and follows patients for up to three months post-therapy, with annual follow-ups continuing beyond this period to monitor long-term effects.

Data Collection for the Assessment of Acute and Late Normal Tissue in Patients Treated With Proton Therapy