What is this study testing for soft tissue sarcoma?

This study is testing a shorter five-day course of preoperative radiation therapy for soft tissue sarcoma. Researchers want to see if this shorter treatment is safe and how well it controls the cancer compared to the standard longer radiation schedule. The study is led by Stanford University to explore more convenient treatment options.

Who may be eligible for this soft tissue sarcoma clinical trial?

Adults aged 18 and older with confirmed soft tissue sarcoma in the extremity, trunk, or retroperitoneum may be eligible. Participants must be candidates for preoperative radiation and surgery, have a good performance status, and not have had previous radiation to the treatment area. Please review eligibility criteria for more details.

Is there any cost to participate in this soft tissue sarcoma clinical trial?

Study-related care, including the radiation treatment and all trial visits, is provided at no cost. However, personal travel and other expenses are not guaranteed to be covered and may vary. Participants should consider these potential costs when deciding to join.

Actively Recruiting

Phase 2

Age: 18Years +

All Genders

ID06087861

Phase 2 Study of 5-Day Preoperative External Beam Radiation for Soft Tissue Sarcoma

Led by Stanford University · Updated on 2026-04-13

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Researchers are evaluating a shorter course of preoperative radiation therapy for patients with soft tissue sarcoma located in the extremity, trunk, or retroperitoneum. This study aims to examine the safety and effectiveness of delivering radiation over five days, compared to the standard treatment which is spread over 25 days. The trial is a Phase 2 study sponsored by Stanford University focused on improving treatment convenience while monitoring outcomes. Participants receive external beam radiotherapy with a total dose of 30 Gy divided into five daily treatments, each delivering 6 Gy. This abbreviated radiation schedule is given prior to surgery, following the standard care plan of preoperative radiation and surgical resection. The study does not include a comparison group and is not blinded. During the trial, participants are monitored for complications occurring up to 120 days after surgery to assess safety. Researchers also track the rate of local cancer recurrence at 2 and 5 years post-surgery. Patients will undergo regular assessments related to treatment response and side effects to evaluate outcomes. Participation duration includes radiation treatment, surgery, and long-term follow-up for cancer control.

CONDITIONS

Brief Title

5-Day Preoperative Radiation for Soft Tissue Sarcoma

Who Can Participate

Age: 18Years +

All Genders

Eligibility Criteria

You may qualify if you...

Histologically confirmed soft tissue sarcoma of the extremity, trunk, or retroperitoneum
Offered preoperative radiation and surgery as part of standard care
Age 18 years or older
Karnofsky Performance Status (KPS) 70 or higher, or ECOG 0 to 2
Life expectancy of at least 6 months
Negative pregnancy test if woman of childbearing potential
Ability to understand and willing to sign informed consent

You will not qualify if you...

Previous radiation to the area to be treated
Current use of other anti-cancer investigational drugs
Planned concurrent chemotherapy, targeted therapy, or immunotherapy with radiation and surgery
Pregnancy

Research Team

Alyssa Yauger

Camellia Djebroun

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