Study of 7-Day Water-Only Fasting or Ketone Supplement Use for Men With Prostate Cancer

What this Trial Is About

Researchers are studying whether 7 days of water-only fasting, a ketogenic very low-calorie diet, or ketone supplementation is safe and feasible for men with prostate cancer, including those with local and metastatic forms of the disease. Current immune-targeting treatments often do not work well for prostate cancer, and animal studies suggest that fasting or ketosis may help the immune system better attack cancer cells. Participants in this trial will be divided into groups based on their cancer type and intervention. Some will follow a 7-day water-only fast followed by a 3-day refeeding period, while others will take a ketone supplement for 7 days. These interventions are being tested for safety and feasibility in both local and metastatic prostate cancer. During the study, participants will be monitored for adverse events and their ability to complete the fasting or supplementation. Quality of life and physical activity will be assessed daily using surveys and step counts from Day 1 to Day 10. Biopsies may be required depending on cancer status. The study will last about 10 days for each participant, with safety and outcomes followed for up to one year.

7-Days Water-Only Fasting or Ketone Supplementation Trial in Prostate Cancer