Pilot Study of Deep Brain Stimulation for Memory and Cognitive Problems After Traumatic Brain Injury in Adults

What this Trial Is About

Traumatic brain injury TBI affects millions worldwide and can lead to lasting cognitive problems such as memory and attention difficulties. Despite progress in treatments and research, some patients continue to suffer from severe cognitive deficits that reduce their quality of life. This trial investigates whether deep brain stimulation DBS, a surgical therapy that has shown promise in improving memory in animal models and Alzheimers patients, is safe and potentially effective for patients with persistent cognitive issues after TBI. In this study, patients will undergo DBS surgery where electrodes are implanted in specific brain areas using a stereotactic frame to guide precise placement. During the procedure, patients remain awake for part of the surgery while local anesthesia is applied. The trial focuses on targeting brain regions associated with memory and cognitive function. DBS has been used successfully in movement disorders and shows potential for treating neuropsychiatric symptoms after TBI. This trial is a pilot phase assessing the feasibility and safety of this approach. Participants will be closely monitored through regular follow-ups over two years to track any treatment-related side effects and evaluate cognitive changes. Assessments include memory tests and safety evaluations conducted every two weeks initially, then less frequently over time. The study also requires participants to comply with scheduled visits and testing. The main outcome measured is the number of participants experiencing adverse events related to DBS treatment during the follow-up period.

DBS for Cognitive Deficits After Traumatic Brain Injury