Actively Recruiting

Phase Not Applicable
Age: 18Years - 80Years
All Genders
ID06755866

DCE-MRI Using 4D Free Breathing to Predict Response to Preoperative Chemoradiotherapy for Esophageal Cancer

Led by Yunnan Cancer Hospital · Updated on 2025-01-01

135

Participants Needed

1

Research Sites

87 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are collecting medical images and clinical data of patients with esophageal cancer using advanced 4D Free Breathing DCE-MRI technology. The study aims to assess how well this imaging method works for diagnosing esophageal cancer and to predict how patients will respond to preoperative neoadjuvant chemoradiotherapy. This approach focuses on improving treatment planning by evaluating tumor response accurately. Participants will undergo chest MRI scans using the 4D Free Breathing DCE-MRI technique, which is performed outside of standard treatment options. This imaging is done before surgery to help predict treatment effectiveness. Surgery is scheduled within one month after the neoadjuvant therapy, and the pathological complete response (pCR) from the surgery results serves as the standard to evaluate tumor response. During the study, researchers will collect imaging and clinical data to analyze tumor responses. The main outcome measured is the tumor's response to treatment, confirmed through pathological examination after surgery. Participants' images will be evaluated for quality and diagnostic usefulness. The study includes follow-up assessments to ensure accurate prediction of treatment outcomes within the study timeline.

CONDITIONS

Official Title

DCE-MRI Based on 4D Free Breathing for Predicting Preoperative Neoadjuvant Chemoradiotherapy for Esophageal Cancer

Who Can Participate

Age: 18Years - 80Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Be 18 years of age and older
  • First diagnosis of esophageal squamous cell carcinoma confirmed by histopathological biopsy
  • Clinical stage is cT1b to cT2 with positive lymph nodes; or clinical stage is cT3 to cT4 any lymph node status (thoracic esophageal cancer or esophagogastric junction cancer)
  • No contraindications to MRI examination
Not Eligible

You will not qualify if you...

  • Have other primary tumors
  • Image quality does not meet diagnostic criteria
  • Do not cooperate with the inspection
  • Have received prior chemoradiotherapy

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

Yunnan Cancer Hospital

Kunming, Yunnan, China

Actively Recruiting

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Research Team

R

ruiling Yang

Z

zhenhui Li

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

Frequently Asked Questions

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DCE-MRI Using 4D Free Breathing to Predict Response to Preoperative Chemoradiotherapy for Esophageal Cancer | DecenTrialz