Actively Recruiting
DCE-MRI Using 4D Free Breathing to Predict Response to Preoperative Chemoradiotherapy for Esophageal Cancer
Led by Yunnan Cancer Hospital · Updated on 2025-01-01
135
Participants Needed
1
Research Sites
87 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are collecting medical images and clinical data of patients with esophageal cancer using advanced 4D Free Breathing DCE-MRI technology. The study aims to assess how well this imaging method works for diagnosing esophageal cancer and to predict how patients will respond to preoperative neoadjuvant chemoradiotherapy. This approach focuses on improving treatment planning by evaluating tumor response accurately. Participants will undergo chest MRI scans using the 4D Free Breathing DCE-MRI technique, which is performed outside of standard treatment options. This imaging is done before surgery to help predict treatment effectiveness. Surgery is scheduled within one month after the neoadjuvant therapy, and the pathological complete response (pCR) from the surgery results serves as the standard to evaluate tumor response. During the study, researchers will collect imaging and clinical data to analyze tumor responses. The main outcome measured is the tumor's response to treatment, confirmed through pathological examination after surgery. Participants' images will be evaluated for quality and diagnostic usefulness. The study includes follow-up assessments to ensure accurate prediction of treatment outcomes within the study timeline.
CONDITIONS
Official Title
DCE-MRI Based on 4D Free Breathing for Predicting Preoperative Neoadjuvant Chemoradiotherapy for Esophageal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be 18 years of age and older
- First diagnosis of esophageal squamous cell carcinoma confirmed by histopathological biopsy
- Clinical stage is cT1b to cT2 with positive lymph nodes; or clinical stage is cT3 to cT4 any lymph node status (thoracic esophageal cancer or esophagogastric junction cancer)
- No contraindications to MRI examination
You will not qualify if you...
- Have other primary tumors
- Image quality does not meet diagnostic criteria
- Do not cooperate with the inspection
- Have received prior chemoradiotherapy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Yunnan Cancer Hospital
Kunming, Yunnan, China
Actively Recruiting
Research Team
R
ruiling Yang
Z
zhenhui Li
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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