Actively Recruiting
Primary Ciliary Dyskinesias: Identification of Specific Severity Criteria and Phenotype-genotype Correlation Study
Led by Institut National de la Santé Et de la Recherche Médicale, France · Updated on 2026-02-12
300
Participants Needed
32
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Primary Ciliary Dyskinesias (PCD) are rare inherited respiratory diseases caused by defects in the structure or function of cilia, leading to problems with clearing mucus from the airways. This condition results in repeated infections in both the upper and lower respiratory tracts, starting in early childhood and potentially causing complications like nasal polyps and bronchial dilation. Half of the patients have a condition called Kartagener's syndrome with organ lateralization defects, and many experience fertility issues. The study aims to improve patient care by identifying factors that predict disease severity and by assessing quality of life and medical conditions related to ENT problems and infertility. It also seeks to identify new genes involved in PCD and explore the relationship between genes and symptoms.
CONDITIONS
Brief Title
DCP (RaDiCo Cohort) (RaDiCo-DCP)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Primary Ciliary Dyskinesia confirmed by Kartagener's syndrome, ciliary ultrastructure anomaly, or a known PCD gene mutation
- Ability to attend at least one annual follow-up visit
You will not qualify if you...
- Unconfirmed diagnosis of Primary Ciliary Dyskinesia
- Presence of an evolving other health condition that may affect assessment of PCD symptoms
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 5 years
Participants are monitored over time to assess disease severity and quality of life through periodic evaluations and questionnaires.
At least 1 annual follow-up visit
Trial Site Locations
Total: 32 locations
1
Hôpital Jean Minjoz
Besançon, France
Not Yet Recruiting
2
Hôpital Pellegrin-Enfants
Bordeaux, France
Not Yet Recruiting
3
CHU de Caen
Caen, France
Not Yet Recruiting
4
Hôpital Clémenceau
Caen, France
Not Yet Recruiting
5
Centre Hospitalier Intercommunal de Créteil
Créteil, France
Actively Recruiting
6
Centre Hospitalier Intercommunal de Créteil
Créteil, France
Not Yet Recruiting
7
Centre Hospitalier Intercommunal de Créteil
Créteil, France
Actively Recruiting
8
Hôpital Henri Mondor
Créteil, France
Actively Recruiting
9
Hôpital Le Bocage
Dijon, France
Not Yet Recruiting
10
Hôpital Bicêtre
Le Kremlin-Bicêtre, France
Actively Recruiting
11
Hôpital Jeanne de Flandre
Lille, France
Actively Recruiting
12
Hôpital Femme-Mère-Enfant
Lyon, France
Actively Recruiting
13
Hôpital Louis Pradel
Lyon, France
Actively Recruiting
14
Hôpital de la Timone
Marseille, France
Not Yet Recruiting
15
Hôpital Nord
Marseille, France
Actively Recruiting
16
Hôpital Arnaud de Villeneuve
Montpellier, France
Actively Recruiting
17
Hôpital Arnaud de Villeneuve
Montpellier, France
Not Yet Recruiting
18
Hôpital Lenval
Nice, France
Not Yet Recruiting
19
Hôpital Armand Trousseau
Paris, France
Actively Recruiting
20
Hôpital Armand Trousseau
Paris, France
Actively Recruiting
21
Hôpital Bichat
Paris, France
Actively Recruiting
22
Hôpital Cochin
Paris, France
Actively Recruiting
23
Hôpital Necker-Enfants Malades
Paris, France
Actively Recruiting
24
Hôpital Robert Debré
Paris, France
Not Yet Recruiting
25
Hôpital Tenon
Paris, France
Actively Recruiting
26
American Memorial Hospital
Reims, France
Actively Recruiting
27
Hôpital Charles Nicolle
Rouen, France
Not Yet Recruiting
28
Hospices Civils
Strasbourg, France
Actively Recruiting
29
Hôpital Hautepierre
Strasbourg, France
Not Yet Recruiting
30
Hôpital des Enfants
Toulouse, France
Actively Recruiting
31
Hôpital Larrey
Toulouse, France
Not Yet Recruiting
32
Hôpital de Clocheville
Tours, France
Not Yet Recruiting
Research Team
B
Bernard MAITRE
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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