Actively Recruiting
De-escalated Radiation for Human Papillomavirus-Positive Squamous Cell Carcinoma of the Oropharynx
Led by University of California, Irvine · Updated on 2026-05-05
111
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a single-arm, observational registry study determining the effects of reduced radiation dose in select patients with human papillomavirus (HPV) positive oropharyngeal cancer.
CONDITIONS
Official Title
De-escalated Radiation for Human Papillomavirus-Positive Squamous Cell Carcinoma of the Oropharynx
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pathologically confirmed diagnosis of HPV-positive oropharyngeal squamous cell carcinoma (p16-positive tumors)
- Clinical stage I, II, or III disease without distant metastases
- History and physical exam including weight assessment within 6 weeks prior to registration
- Age 18 years or older
- PET/CT scan within 6 weeks prior to registration
- Signed study-specific informed consent form
- Both men and women of all races and ethnic groups eligible, including non-English speakers, deaf, hard of hearing, and illiterate individuals
You will not qualify if you...
- Prior invasive malignancy within the last 3 years except non-melanomatous skin cancer
- Prior surgical treatment beyond diagnostic biopsy or nodal sampling for this cancer
- Prior systemic chemotherapy for this oropharyngeal cancer
- Previous radiotherapy overlapping the proposed treatment area
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Chao Family Comprehensive Cancer Center, University of California, Irvine
Orange, California, United States, 92868
Actively Recruiting
Research Team
C
Chao Family Comprehensive Cancer Center University of California, Irvine
CONTACT
U
University of California Irvine Medical
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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