Study Comparing Dead Space Ventilation in Mechanical Ventilation Using Flow-Controlled vs Volume-Controlled Methods During Surgery

What this Trial Is About

Researchers are investigating differences in dead space ventilation, which is the ventilation of poorly perfused lung areas, during two types of mechanical ventilation: conventional volume-controlled ventilation and a newer flow-controlled ventilation. Dead space ventilation is important because it relates to lung stress and is a predictor of mortality in conditions like acute respiratory distress syndrome. This study focuses on patients undergoing general anesthesia for elective surgery who require mechanical ventilation. Participants will receive two types of ventilation during surgery: 20 minutes of flow-controlled ventilation using the Evone ventilator and 20 minutes of conventional volume-controlled ventilation using either the Aisys CS3 or Flow-i ventilators. Both ventilation modes involve controlled mechanical ventilation while the patient lies in a supine position. The study compares the amount of wasted ventilation during these two methods. During the study, participants will be monitored with standard care devices including arterial and central venous lines and an endotracheal tube. Researchers will measure changes in dead space ventilation over 20 minutes for each ventilation type. The study assesses ventilation efficiency and safety over the course of surgery, with mechanical ventilation expected to last at least 60 minutes. Data collected will help understand how different ventilation methods affect lung function during surgery.

Dead Space in Mechanical Ventilation With Constant Expiratory Flow