Actively Recruiting
Debunking the Frailty-sarcopenIa-ADT Axis in mEtastatic Prostate canceR With multiComponent Exercise: The FIERCE Trial
Led by Dana-Farber Cancer Institute · Updated on 2026-03-11
80
Participants Needed
3
Research Sites
164 weeks
Total Duration
On this page
Sponsors
D
Dana-Farber Cancer Institute
Lead Sponsor
P
Prostate Cancer Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to determine whether a 16-week supervised, clinic-based circuit training intervention utilizing resistance and functional exercises and self-directed aerobic exercise will improve frailty and sarcopenic status and disease progression outcomes among pre-frail/frail metastatic prostate cancer patients receiving androgen deprivation therapy (ADT). The names of the study intervention involved in this study is: • Supervised circuit training (aerobic and resistance exercise regimen)
CONDITIONS
Official Title
Debunking the Frailty-sarcopenIa-ADT Axis in mEtastatic Prostate canceR With multiComponent Exercise: The FIERCE Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to understand and willingness to sign informed consent before any study procedures
- Diagnosed with metastatic prostate cancer
- Age 18 years or older
- Receiving androgen deprivation therapy (with or without androgen receptor targeted treatment) for at least one month and expected to continue for at least 4 months
- Pre-frail or frail based on the FRAIL scale (score 1-2 = pre-frail; 3-5 = frail)
- Physician clearance to participate in exercise
- Speak English
- Engaged in less than 2 structured resistance exercise sessions per week in the last 4 months
- Participated in 60 minutes or less of moderate-to-vigorous aerobic exercise per week in the last month
- Willing to travel to Dana-Farber Cancer Institute for data collection and exercise sessions
You will not qualify if you...
- Currently receiving chemotherapy
- Have unstable bone lesions or severely symptomatic bone metastases
- Completed 2 or more resistance exercise sessions per week in the last 4 months and more than 60 minutes of moderate-to-vigorous aerobic exercise per week in the last month
- Have unstable comorbidities that prevent moderate-to-vigorous intensity exercise
- Receiving treatment for other active cancers (except basal cell carcinoma)
- Unable to comply with study safety monitoring requirements according to investigators
AI-Screening
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Trial Site Locations
Total: 3 locations
1
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Not Yet Recruiting
2
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02215
Actively Recruiting
3
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Not Yet Recruiting
Research Team
C
Christina Dieli-Conwright, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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