Comparing Kidney Transplant Outcomes Using Kidneys Stored at 10C Versus Conventional Ice Storage

What this Trial Is About

This trial investigates how the storage temperature of deceased donor kidneys affects kidney function after transplant in adult patients. It aims to compare kidney transplants stored at 10C versus the conventional storage on ice at 4C to determine if storage at 10C leads to better post-transplant kidney function. The study addresses delayed graft function, a common complication after kidney transplant, caused by ischemic reperfusion injury during organ storage. The trial involves two groups one receiving kidneys stored at 10C using the Traferox XPort device that maintains this temperature during storage and transport, and the other receiving kidneys stored conventionally on ice. Kidneys stored at 10C come from participating organ procurement organizations, while others are stored on ice. Transplants proceed following usual clinical practice, with identical immunosuppression protocols for both groups. Participants will have urine collected 24 hours after surgery for research analysis, including measurement of urine NGAL as the primary outcome. Routine clinical information, such as delayed graft function within 7 days and kidney function trends over one month, will also be monitored. Data will be gathered from medical records, and participant involvement continues through the transplant and immediate post-operative period.

Deceased Donor Kidney Storage at 10 Celsius Versus Conventional Storage