Actively Recruiting
DEciphering CIrculating SIgnatures Of Infected Pancreatic Necrosis
Led by University of Minnesota · Updated on 2025-07-14
45
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating new blood-based markers to predict and diagnose infected pancreatic necrosis (IPN) in patients with necrotizing pancreatitis (NP), a serious complication of acute pancreatitis (AP). AP causes inflammation and damage to the pancreas, leading to tissue death in about 20% of cases. IPN can cause severe complications including organ failure, sepsis, and high mortality, highlighting the need for better early detection methods. This observational study involves patients diagnosed with NP confirmed by imaging and enrolled within two weeks of acute pancreatitis onset. Participants will be monitored locally through the University of Minnesota and M Health Fairview system. The study does not involve any experimental treatments but focuses on collecting clinical data and blood samples to identify immune and metabolic changes and novel biomarkers related to IPN. Participants will undergo assessments over a three-month period to understand immune-metabolic changes and discover new biomarkers. Researchers will track disease progression and outcomes without introducing treatments. The study aims to improve prognosis and guide therapy decisions by filling the current diagnostic gap. The total participation duration for outcome measurement is three months.
CONDITIONS
Brief Title
DEciphering CIrculating SIgnatures Of Infected Pancreatic Necrosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged >18 years
- Diagnosis of necrotizing pancreatitis based on contrast-enhanced computed tomography (CECT)
You will not qualify if you...
- Recurrent acute pancreatitis
- Pancreatic cancer
- Pregnancy or lactation
- Solid organ transplant
- Immunodeficiency disorders like AIDS
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 3 months
Participants are observed to understand immune-metabolic dynamics and identify biomarkers related to necrotizing pancreatitis.
Trial Site Locations
Total: 1 location
1
University of Minnesota
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
Research Team
P
Petr Vanek, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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